نتایج جستجو برای: excitotoxicity
تعداد نتایج: 2624 فیلتر نتایج به سال:
Seizure-driven brain damage in epilepsy accumulates over time, especially in the hippocampus, which can lead to sclerosis, cognitive decline, and death. Excitotoxicity is the prevalent model to explain ictal neurodegeneration. Current labeling technologies cannot distinguish between excitotoxicity and hypoxia, however, because they share common molecular mechanisms. This leaves open the possibi...
Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system. The excessive release of glutamate and exaggerated stimulation of post-synaptic glutamate receptors are involved in the process known as excitotoxicity. Excitotoxicity has been widely implicated in neuronal damage following an ischaemic episode and the ensuing reperfusion [ I ] . The neonatal brain is know...
Introduction: Sex differences in outcomes of Spinal Cord Injury (SCI) suggest a sex-hormone-mediated effect on post-SCI pathological events, including glutamate excitotoxicity. This study aimed to investigate the importance of gonadal hormones on glutamate release subsequent to SCI in rats. Methods: After laminectomy at T8-T9, an electrolytic lesion was applied to the spinothalamic tracts of m...
Neurodegeneration is the pathophysiological basis for permanent neurological disabilities in multiple sclerosis (MS); thus neuroprotection is emerging as a therapeutic approach in MS research. Modulation of excitotoxicity by inhibition of NMDARs has been suggested for neuroprotection, but selective antagonisation of the NR2B subtype of these receptors, a subtype believed to play a more pivotal ...
Background DHA-H (Hydroxy-docosahexaenoic acid) is a molecule in development for Alzheimer’s disease (AD) treatment based on the concept of membrane lipid therapy (melitherapy). Once entered cell, metabolized via α-oxidation to fatty acid HPA (Heneicosapentaenoic acid). has been shown reduce amyloidogenic processing Amyloid Precursor Protein (APP), as well having neuroprotective effect cellular...
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