The effects of sensory deprivation on excitatory and inhibitory activity in the primary somatosensory cortex were studied in the adult rat. Excitatory and inhibitory transmission generated by whisker stimulation, and neuronal responsiveness to iontophoretically applied excitatory amino acids were recorded. Whisker input deprivation, through whisker trimming for a median of 24 days, resulted in ...

We quantified the effect of the excitatory amino acids kainate and glutamate on the uptake of cobalt in primary rat cerebellar granule neurons, by using inductively coupled plasma-atomic emission spectroscopy (ICP-AES). We quantitatively demonstrated that Co2+ uptake, although enhanced by glutamate and kainate also takes place in the absence of excitatory amino acids. We also found that cobalt ...

The dicarboxylic amino acids, glutamate and aspartate, are excitatory neurotransmitters in many brain regions. Recent animal experiments with analogues of dicarboxylic amino acids that block their excitatory actions, suggest that such selective antagonists could have important therapeutic uses in neurology and psychiatry. The strongest evidence concerns epilepsy and disorders of the motor syste...

1. The Fundamental Assumptions.-Denote by Sap the components of the deviation s of the stress tensor a. Let va be the components of the velocity vector v and efa the components of the rate of strain tensor e derived from the velocity vector. We impose the usual condition that the flow is incompressible, i.e., eaa = 0, which appears to be in agreement with experimental evidence. Hence e is ident...

42 Introduction 43 Methods 44 Results 49 Discussion..... 68 References 74 CHAPTERS. ATP-EVOKEDCa2+-DEPENDENT RELEASE OF EXCITATORY AMINO ACIDS FROM CULTURED SCHWANN CELLS 81 Abstract... 8

Protein synthesis in brain slices was followed by the incorporation of 14C-amino acid, mostly r4C-valine; it remained steady for at least 4 hours at 37”. When applied for 15 min or longer, electrical stimulation of slices, by use of alternating line current reduced to 0.5 to 3 volts, inhibited protein synthesis increasingly, the inhibition reaching a plateau at 1.5 volts. For comparison, the pa...