Peptide therapeutics hold attractive potential. However, the proper stabilization of such therapeutics remains a major challenge. Some peptides are marginally stable and are prone to degradation. Therefore, in addition to chemical modifications that can be introduced in their sequence, a wide variety of excipients are added in the formulation to stabilize them, as is also done routinely for pro...

In the present era of diverging pharmaceuticals upcoming in the market, those from that of natural origin are gaining increasing importance. In this context, starch when obtained from natural source has high orientation to be used as pharmaceutical excipient. Among the natural sources, in the present review we have discussed about Metroxylon sagu i.e. sago starch as a potential source to be use...

Excipients represent diverse classes of molecules, small molecules or macromolecules, with versatile structures within a given class and are from natural, semi-synthetic and synthetic sources. They are essential ingredients in drug products independently of the route of administration where both traditional and non-traditional uses are present. Beyond their traditional use as formulation and ma...

Development of peptide therapeutics generally involves screening excipients that inhibit peptide-peptide interactions, hence aggregation, and improve stability. We used the therapeutic plectasin to develop a fast method combines microscale thermophoresis titration assays molecular dynamics simulations relatively rank with respect binding affinity study key peptide-excipient interaction hotspots...

Airaksinen, S.T.T., 2005. Role of excipients in moisture sorption and physical stability of solid pharmaceutical formulations. Dissertationes bioscientiarum molecularium Universitatis Helsingiensis in Viikki, 20/2005, pp. 57, ISBN 952-10-2733-9 (print) ISBN 952-10-2734-7 (pdf) ISSN 1795-7079 The interaction of moisture with pharmaceutical solids is crucial to an understanding of water-based pro...

Cyclosporin A (CsA), a potent immunosuppressor used in organ transplants and autoimmune diseases, is associated with adverse effects in the kidney, liver, and nervous system. This drug was recently shown to stimulate platelet aggregation, to increase thromboxane synthesis, and to decrease vascular prostacyclin synthesis. In experimental cholestasis, thrombocyte function is altered. The present ...

Objective: the objective of the present work was extraction of polysaccharide from tamarind seed and further characterization as pharmaceutical excipient. study includes phytochemical screening, micromeritic properties. Work also emphasize to study gelling properties of extracted polysaccharide. Methods: Water based extraction procedure was used to extract polysaccharide from tamarind seed. Pha...

This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll compaction (RC). Differential scanning calorimetry (DSC), Fourier transform-In...

BACKGROUND Little is known about exposure of preterm infants to excipients during routine clinical care. OBJECTIVE To document excipient exposure in vulnerable preterm babies in a single centre, taking into account chronic lung disease (CLD) as a marker of illness severity. DESIGN Excipient exposure after treatment with eight oral liquid medications was determined by retrospectively analysi...