This study reports on L-carnosine phytosomes as an alternative for the prodrug N-acetyl-L-carnosine as a novel delivery system to the lens. L-carnosine was loaded into lipid-based phytosomes and hyaluronic acid (HA)-dispersed phytosomes. L-carnosine-phospholipid complexes (PC) of different molar ratios, 1:1 and 1:2, were prepared by the solvent evaporation method. These complexes were character...

objective(s): ex vivo expansion of hematopoitic stem cells is an alternative way to increase umbilical cord blood (ucb)-cd34+ cells for bone marrow transplantation. for this purpose demineralized bone matrix (dbm) and mineralized bone allograft (mba) as two scaffolds based on bone matrix and stem cell niche, were simultaneously used to enhance the effect of human mesenchymal progenitor cells (m...

BACKGROUND AND THE PURPOSE OF THE STUDY Domperidone (DOM) is a dopamine- receptor (D(2)) antagonist, which is widely used in the treatment of motion-sickness. The pharmacokinetic parameters make DOM a suitable candidate for transdermal delivery. The purpose of the present investigation was to develop transdermal delivery systems for DOM and to evaluate their physicochemical characteristics, in ...

Nasal solutions of almotriptan malate were prepared in phosphate buffer containing different proportions of HPMC E15. In vitro permeation studies were performed using Franz diffusion cell with dialysis membrane and ex vivo permeation studies were carried out using sheep nasal mucosal layer. The formulations were radiolabeled with 99mTc and the nasal residence time was studied in rabbits. Nasal ...

Transdermal delivery of ondansetron hydrochloride is one of the promising ways to maximize the therapy in contrast to oral delivery. Current investigation efforts are focused in formulating the ondansetron hydrochloride matrix-type transdermal film by incorporating hydrophilic and hydrophobic polymers. In this study, ondansetron hydrochloride transdermal films were prepared using solvent evapor...

An objective of periodontal treatment is to suppress or eliminate sub gingival periodontal pathogens. Local delivery devices for periodontitis are designed to deliver the drug locally into periodontal pocket. Satranidazole is a 5-nitroimidazole derivative active against gram negative anaerobic periodontal infections. For site specific one time continuous delivery of Satranidazole, an antimicrob...

The aim of the present study was to investigate transfersomes as a transdermal delivery system for the poorly soluble drug, sertraline, in order to overcome the troubles associated with its oral delivery. Different transfersomal formulations were prepared with non-ionic surfactant (span 80), soya lecithin, and carbopol 940 by the rotary evaporation sonication method. The prepared formulations w...

Candesartan cilexetil (CC) is an angiotensin II-receptor blocker (ARB). The antihypertensive effect of CC 4-16 mg/day was as great that other once-daily dosage regimens. has high first-pass metabolism and low oral bioavailability. bioavailability such drugs may be significantly improved if delivered through the buccal route; hence mucosal delivery one alternative methods systemic drug delivery....

Objective: Rheumatoid arthritis is treated with aceclofenac as the first line of treatment. Aceclofenac a BCS-II drug, when taken orally, causes first-pass metabolism and partially water-insoluble causing some gastrointestinal (GI) issues. Objective work was preparation evaluation solid lipid nanoparticle for rheumatoid increases drug permeability further possibility to decreasing irritation. M...

The present study aimed to investigate the delivery potential of Etodolac (ETD) containing topical niosomal gel. Niosomal formulations were prepared by thin film hydration method at various ratios of cholesterol and Span 60 and were evaluated with respect to particle size, shape, entrapment efficiency, and in vitro characteristics. Dicetyl phosphate (DCP) was also added in the niosomal formulat...