نتایج جستجو برای: evolving enhancer protein

تعداد نتایج: 1295154  

Journal: :Journal of bacteriology 1995
F Wu I Levchenko M Filutowicz

The plasmid R6K gamma origin consists of two adjacent modules, the enhancer and the core, and requires R6K initiator protein pi for replication. While the core alone can replicate at a low level of wild-type pi protein, we show here that host cells do not stably maintain core plasmids. The presence of the enhancer segment confers stable inheritance on core plasmids without a significant change ...

Journal: :The Journal of Experimental Medicine 1990
I C Ho J M Leiden

T cell-specific expression of the human T cell receptor alpha (TCR-alpha) gene is regulated by the interaction of variable region promoter elements with a transcriptional enhancer that is located 4.5 kb 3' of the TCR-alpha constant region (C alpha) gene segment. The minimal TCR-alpha enhancer is composed of two nuclear protein binding sites, T alpha 1 and T alpha 2, that are both required for t...

Journal: :Nucleic acids research 1994
Y Fujimura H Yamamoto F Hamazato M Nozaki

Expression of the mouse cytokeratin EndoA gene is restricted in endodermal and epithelial cells, and is regulated by an enhancer that is located 1 kilobase (kb) 3' downstream from the gene. The enhancer consists of six direct repeats, of which each contains two predicted Ets binding sites (EBS1 and EBS2) containing GGAA as a core. Mutation analysis showed that EBS1 is essential for the enhancer...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1991
J Marine A Winoto

The tissue-specific developmental regulation of the alpha, beta, gamma and delta T-cell antigen receptor (TCR) genes is controlled by the corresponding distinct enhancers and their enhancer-binding proteins. To find a common TCR regulatory element, we have studied the ability of the newly described enhancer-binding protein Gata3 to bind to the sequence motif (A/T)GATA(G/A) shared between enhanc...

Journal: :Molecular and cellular biology 2000
K Tanaka Y Matsumoto F Nakatani Y Iwamoto Y Yamada

Transcription of the type II collagen gene (Col2a1) is regulated by multiple cis-acting sites. The enhancer element, which is located in the first intron, is necessary for high-level and cartilage-specific expression of Col2a1. A mouse limb bud cDNA expression library was screened by the Saccharomyces cerevisiae one-hybrid screening method to identify protein factors bound to the enhancer. A zi...

Journal: :Molecular and Cellular Biology 1989

Journal: :iranian journal of pharmaceutical research 0
e moghimipour a jalali sa sajjadi tabassi r l?benberg

there have been numerous efforts to formulate insulin into an oral dosage form. the major problems involved with the oral administration of insulin are acidic and enzymatic decomposition by the gastric medium, and poor absorption in the small intestine due to its macromolecular structure. this study attempted to test the enhancing ability of two absorption enhancers, sodium glycocholate (na-gc)...

Journal: :Acta biochimica et biophysica Sinica 2008
Hua Zhong Zhigang Jin Yongfeng Chen Ting Zhang Wei Bian Xing Cui Naihe Jing

Nestin is an intermediate filament protein expressed in neural progenitor cells and in developing skeletal muscle. Nestin has been widely used as a neural progenitor cell marker. It is well established that the specific expression of the nestin gene in neural progenitor cells is conferred by the neural-specific enhancer located in the second intron of the nestin gene. However, the transcription...

Journal: :Cell 2007
Daniel Panne Tom Maniatis Stephen C Harrison

Transcriptional activation of the interferon-beta (IFN-beta) gene requires assembly of an enhanceosome containing ATF-2/c-Jun, IRF-3/IRF-7, and NFkappaB. These factors bind cooperatively to the IFN-beta enhancer and recruit coactivators and chromatin-remodeling proteins to the IFN-beta promoter. We describe here a crystal structure of the DNA-binding domains of IRF-3, IRF-7, and NFkappaB, bound...

2004200520062007200820092010201120122013201420152016201720182019202020212022202304000080000

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید