a stability indicating high-performance liquid chromatography (hplc) method wasvalidated and used to study the degradation of cetirizine dihydrochloride in acidic and oxidativeconditions. the separation was carried out on a symmetry c18 column and a mixture of 50 mmkh2po4 and acetonitrile (60:40 v/v, ph = 3.5) was used as the mobile phase. the method waslinear over the range of 1-20 μg/ml of ce...

In order to reduce dosing frequency, a sustained release dosage form of betahistine dihydrochloride was developed as a twice daily controlled release tablet formulation that could be used to decrease vertigo resulted in Meniere's disease for a prolonged time. Six formulations were developed by using Methocel K4M CR, Methocel K15M CR and Methocel K 100 LVCR as single and combinations in differen...

A stability indicating High-Performance Liquid Chromatography (HPLC) method wasvalidated and used to study the degradation of cetirizine dihydrochloride in acidic and oxidativeconditions. The separation was carried out on a Symmetry C18 column and a mixture of 50 mMKH2PO4 and acetonitrile (60:40 v/v, pH = 3.5) was used as the mobile phase. The method waslinear over the range of 1-20 μg/mL of ce...

The cancer potencies of 3,3'-dimethoxybenzidine dihydrochloride (commonly called odianisidine) and 3,3'-dimethoxybenzidine dihydrochloride were estimated from dose-response data for multiple treatment-responding tumor sites among male rats exposed orally to 3,3'dimethoxybenzidine dihydrochloride via drinking water (NTP, 1990). These sites were skin, Zymbal’s gland, preputial gland, small intest...

Objectives: The aim of this study is to gain insight into the mechanism of the antimicrobial action of a novel arginine-based surfactant, bis(N-caproyl-L-arginine)-1,3-propanediamine dihydrochloride [C3(CA)2]. Methods: To this end, we compared its effects against Staphylococcus aureus and Escherichia coli with those caused by the commercial and widely known antiseptic, chlorhexidine dihydrochlo...

The observation that aliphatic diamines become poor substrates as the carbon chain length decreases and that ethylenediamine, the shortest diamine, is an irreversible inhibitor of lysyl oxidase led to the investigation of the mechanism of inhibition by ethylenediamine. The cis but not the trans isomer of 1,2-diaminocyclohexane was also a potent irreversible inhibitor of lysyl oxidase, consisten...

Pseudomonas aeruginosa is one of the most frequently isolated organisms from infected burn wounds and a significant cause of nosocomial infection and septic mortality among burn patients. In this animal study, three antiseptic agents which were Octenidine dihydrochloride (Octenisept®, Schülke & Mayr, Norderstedt, Germany), polyhexanide (Prontosan®, B. Braun, Melsungen AG, Germany) and povidon i...