Introduction: Keratoconus is an ectasia that results in corneal thinning in central and paracentral areas of affected corneas. This disease occurs most frequently in young males, underlying a potential role of sex hormones in its pathogenesis. By examining the expression of sex hormone receptors, this study aimed to reveal potential roles of the sex hormone receptors in keratoconus pathogenesis...

AIB1 was isolated as a gene amplified in breast cancer and encodes a protein that acts as a steroid receptor coactivator. The role of steroid receptor coactivators such as AIB1 in breast cancer development is not clear. It is possible that AIB1 cooperates with estrogen receptor alpha in regulating estrogen-dependent cell proliferation. Ectopic expression of the estrogen receptor alpha in differ...

background:estrogens play a substantial role in the proliferation, progression and treatment of breast cancer by binding with two estrogen receptors, alpha and beta (erα and erβ). resistance to endocrine therapy is a major problem in the treatment of breast cancers and, in some cases, may be related to loss of er gene expression. we have already showed that erα methylation occurs in high freque...

OBJECTIVE To observe the effects of recipe for invigorating kidney on expression of estrogen receptors in ovariectomized rats. METHODS The rats, which were given high-cholesterol diet after ovariectomy, were chosen as experimental subjects. After fed kidney-invigorating recipe for 16 weeks, the rats were killed and the levels of serum lipid and estradiol of these rats were examined. The expre...

Several observations suggest that sex steroids might participate in steady state regulation of B lymphopoiesis. B cell precursors decline dramatically in bone marrow of pregnant or estrogen-treated mice. Reciprocally, the same cell populations are increased in hypogonadal mice or male castrates. Estrogen treatment of hypogonadal mice reduced precursors to normal. However, questions remain about...

Estrogen is an important hormone for health in both genders. It indispensable to glucose homeostasis, immune robustness, bone health, cardiovascular and neural functions. The main way that estrogen acts the cells through receptors (ERs). presence of specific required have its characteristic ubiquitous action almost all tissues. receptor alpha (ER?) beta (ER?) are major isoforms highly humans en...

BACKGROUND Prostate cancer is the second leading cause of death among men in Western countries. Genetic alterations of the estrogen receptor gene are known to be indicative of a higher risk of this disease. The estrogen receptor gene is found as two subtypes, alpha and beta. In this study the estrogen receptor alpha and beta genes were tested in 2 human prostate cancer cell lines: the hormone-s...

Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERalpha and ERbeta was determined. Among compounds tested, the 2-nitrophenol derivative 5c was found to bind satisfactorily to both estrogen receptor subtypes (RBAalpha=5.17 and RBAbeta=3.27). In general, the intro...

OBJECTIVE We showed that 17beta-estradiol (E(2)) favors pancreatic beta-cell survival via the estrogen receptor-alpha (ERalpha) in mice. E(2) activates nuclear estrogen receptors via an estrogen response element (ERE). E(2) also activates nongenomic signals via an extranuclear form of ERalpha and the G protein-coupled estrogen receptor (GPER). We studied the contribution of estrogen receptors t...