Copper deficiency is likely an underrecognized cause of anemia and neutropenia and may masquerade as a myelodysplastic syndrome (MDS). We report 2 cases of copper deficiency in which the diagnosis was suggested based on the characteristic morphologic findings, such as cytoplasmic vacuolization of erythroid and myeloid precursors and iron-containing plasma cells. It is interesting that both pati...

Copper is an essential micronutrient in humans and is required for a wide range of physiological processes, including neurotransmitter biosynthesis, oxidative metabolism, protection against reactive oxygen species, and angiogenesis. The first step in the acquisition of dietary copper is absorption from the intestinal lumen. The major human high-affinity copper uptake protein, human copper trans...

appear to bind copper in these disease states but are not known to do so in vitro. In at least 1 case, the coppercarrying protein was sequenced in an attempt to determine whether it shared the N-terminal Asp-Ala-His amino acid sequence known to bind copper in albumin, but no such sequence was found. Sequences as simple as Gly-His are capable of binding copper under certain circumstances, especi...

Clinical studies have been reported over the last 5 years showing that copper improves the performance of intrauterine devices. Reports by Zipper, Medal, and Prager, 1 and Tatum and Zipper2 have substantiated a positive correlation between the surface area of copper applied to an IUD and its effectiveness both in lower mammals1 and in humans.2 The application of copper to Loop A3• 4 also has be...

Thermodynamic calculations have shown that hydrogen from atmospheric water vapors can penetrate aluminum, iron and copper, especially into their melts. Hydrogen atoms in these metals are free adsorbed states. Strong dense oxide films on the surfaces of copper significantly reduce solubility metals. Copper nanocrystals more actively adsorb atomic than aluminum nanocrystals. This is one main reas...

BACKGROUND/AIMS The differential diagnosis of Wilson Disease (WD) is challenging, especially in children, because liver copper levels may also increase in other chronic liver diseases with bile stasis. The aim of this study is to determine urine and liver copper cut-off values to differentiate WD from other chronic liver diseases (non-WD, NWD) in children. MATERIALS AND METHODS Seventy-six pa...

During development, the fetus is entirely dependent on the mother for its nutrient requirements. Subsequently, it is a period when both are vulnerable to changes in dietary supply, especially of those nutrients that are marginal under normal circumstances. In developed countries, this applies mainly to micronutrients. Even now, iron deficiency is a common disorder, especially in pregnancy. Simi...

CONTEXT Copper deficiency myelopathy represents an often underdiagnosed, acquired neurological syndrome, clinically characterized by posterior column dysfunction. The main causes of copper deficiency are bariatric surgery, increased consumption of zinc, and malabsorption. However, even after a careful history taking and extensive laboratory researches, the etiology of copper deficiency remains ...

Copper has two key properties that are being exploited in consumer and medical device products in the last decade. On the one hand, copper has potent biocidal properties. On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body. In the skin, copper is involved in the synthesis and sta...

The insulating performance of oil is vulnerable to particles especially the conductive particles. This paper investigated the influence of copper particles of micrometer size on the breakdown strength and frequency-dependent properties of vegetable oil. The AC breakdown voltage of contaminated vegetable oil with copper particles of different numbers (ranging from 103 to 106) was measured. The f...