Journal:
:jundishapur journal of microbiology
0
payam dindoost iran hepatitis network, tehran, ir iran
seyed mohammad jazayeri hepatitis b molecular laboratory-department of virology-school of public health-tehran university of medical sciences, tehran, ir iran
hadi karimzadeh hepatitis b molecular laboratory-department of virology-school of public health-tehran university of medical sciences, tehran, ir iran
esmaeil saberfar research center for applied virology, baqiyatallah, university of medical sciences, tehran, ir iran
seyed mohammad miri baqiyatallah university of medical sciences, baqiyatallah research centre for gastroenterology and liver disease, tehran, ir iran
seyed moayed alavian baqiyatallah university of medical sciences, baqiyatallah research centre for gastroenterology and liver disease, tehran, ir iran; corresponding author: seyed moayed alavian, baqiyatallah university of medical sciences, baqiyatallah research centre for gastroenterology and liver disease, tehran, ir iran. +98-2188945186-8, fax: +98-2181262072, e-mail:
abstract mutations have been described in all of the four open reading frames of the hepatitis b virus (hbv), however, from a clinical perspective the surface escape mutant is the most troublesome. hepatitis b surface antigen (hbsag) variants may impair diagnosis, or allow the virus to escape vaccine-induced immunity or passive immunoglobulin therapy. hbv mutants with amino acid substitutions, ...