The oral administration of crushed enteric-coated tablets of erythromycin base to foals suppressed the pulmonary inflammatory response induced by bronchoalveolar lavage. The systemic bioavailability of erythromycin base was low and variable (19.8 6 8.8%), likely as a result of degradation of a substantial portion of the administered dose to microbiologically inactive anhydroerythromycin in the ...

A liquid chromatographic method was developed and validated for the determination of erythromycin an oxime and related substances. The chromatographic analysis was performed on Inertsil C18 ODS column, using the phosphate buffer solution (0.02 M, pH 6.5)-acetonitrile (40:60, V/V) as the mobile phase. Wavelength of the UV detector was 215 nm. All four related substances, including Z isomer of er...

COMMUNICATIONS TO THE EDITOR 713 Saravolatz and co-workers2 documented the lower levels of erythromycin while treating patients with Legionnaires’ disease with oral erythromycin and one of their patients developed Legionnaires’ disease ( LD) while receiving oral erythromycin. Among the antibiotics, rifampin has been shown in vitro to be more active than erythromycin against the LD bacterium. On...

The commonly accepted biosynthetic pathway1) leading to erythromycin A (I) requires that substrate for sugars (L-mycarose and Ddesosamine) attachment should be erythronolide B (IV). Once both sugars are linked to the aglycone, giving rise to erythromycin D, C-12 hydroxylation would occur resulting in erythromycin C production. Erythromycin C is further converted to erythromycin A by O-methylati...

CONTEXT Household contacts of patients with pertussis are at increased risk of acquiring infection. Chemoprophylaxis has been recommended to decrease transmission, particularly to young infants who are at increased risk of severe disease. Although epidemiologic investigations of outbreaks have suggested a benefit, there have been no prospective studies evaluating the efficacy of chemoprophylaxi...

Low-dose long-term erythromycin treatment has recently been reported to be very effective in patients with chronic respiratory infection and inflammation. This effect of erythromycin was thought to be not antibacterial but anti-inflammatory. However, the exact mechanism of the effect of erythromycin has not yet been clarified. The aims of this study were to investigate the effects of erythromyc...

Staphylococcus aureus has been consistently isolated from a high proportion of impetiginous lesions, and in several recent studies, it was present in the majority of the cases. Since recently a large proportion of S. aureus strains in our community showed erythromycin resistance, we undertook a prospective double-blind controlled study comparing topical mupirocin with oral erythromycin to deter...