Erythromelalgia (EM) is a rare disabling clinical syndrome more commonly known to affect the lower extremities. There is no single effective treatment for this disease that often requires a multidisciplinary approach. Herein, we report the case of a 31-year-old woman affected by primary erythromelalgia who was successfully treated with intrathecal Ziconotide. We also observed an unexpected resu...

In this paper, a new class of second order ( , )   -univex and second order ( , )   pseudo univex function are introduced with example. A pair Mond-Weir type second order mixed symmetric duality for multiobjective nondifferentiable programming is formulated and the duality results are established under the mild assumption of second order ( , )   univexity and second order pseudo univexity...

Superficially, Raynaud's phenomenon, a disease associated with cold, and erythromelalgia, a warmth related disorder, could be considered the antithesis of each other. However, both these microcirculatory disorders, first described in the second half of the nineteenth century, have many features in common and, indeed, may share the same etiology, that is microvascular ischemia. The complicated s...

Current weather indifferent fields of science and engineering research purposes and different applications are studied. One of the applications of climate studies, the study of the flow over the weir dam and lower exhaust tunnel is aimed at preventing the risk of cavitations. Aeration is known as one of the most economical and practical way to deal with cavitations on rapid spill ways. In the s...

A 54-year-old man complained of burning pain, warm skin and erythema in his extremities. A diagnosis of primary erythromelalgia was made. Microneurography was used to clarify the role of skin sympathetic nerve activity in the pathophysiology of primary erythromelalgia. The patient showed normal skin sympathetic nerve activity but no vasoconstriction response. Aspirin activated the skin sympathe...

We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Na(v)1.7. The patient reported severe ongoing foot pain, which was exquisitely sensitive to limb cooling. We confirmed this heat hypersensitivity using quantitative sensory testing. Additionally, we employed a novel perfusion imaging technique in a simple block design...

Erythromelalgia is characterized by burning pain, erythema, and increased temperature in acral skin. The pain is aggravated by warming and relieved by cooling. Increased microvascular arteriovenous shunting in deep dermal plexa has been hypothesized as the pathogenetic mechanism of pain in affected skin, inducing hypoxia during pain attacks. The aim of this study was to quantify skin capillary ...