Malignant change occurring at the site of a stoma in two patients with proved Crohn's disease is described. Patients with ulcerative colitis have an increased risk of colonic malignancy and Crohn's disease is also associated with both small and large bowel carcinoma. Most previous reports of stomal carcinoma have been associated with ulcerative colitis although Crohn's disease seems to carry a ...

background: keratinocyte growth factor (kgf) is a potent epithelial mitogen that acts by binding the kgf receptors (kgfrs) expressed on epithelial cells and regulates proliferation and differentiation. the objective of this study was to investigate the expression of kgf in the epithelium in oral precancer. materials and methods: archival tissues of oral submucous fibrosis (smf) and leukoplakia ...

Immunofluorescence staining for carcinoembryonic antigen, secretory component, and epithelial IgA was evaluated semiquantitatively in routine formalin-fixed mucosal biopsy samples from five patients with ulcerative colitis who had undergone colectomy because of carcinomas. Selected areas were given fluorescence intensity scores without knowledge of whether dysplasia or reactive hyperplasia was ...

The natural history of gastric epithelial dysplasia and its relation to gastric cancer are ill defined. A consecutive series of 40 patients with an initial diagnosis of gastric epithelial dysplasia based on examination of endoscopic biopsies has been reviewed to determine the clinical outcome and to evaluate a two tier histological grading system as a predictor of the risk of cancer. On review,...

Background: The progression of oral epithelial dysplastic lesions into oral squamous cell carcinoma is characterized by an ‘angiogenic switch’ which is characterized by an increase in neo-vascularization in the subepithelial lamina propria which can be considered an indicator of malignant transformation. Mast cells are a rich source of various angiogenic factors. Moreover mast cells secrete var...

Approximately 23,000 new gastric cancer cases and 12,000 associated deaths occur annually in the United States. Intestinal metaplasia and gastric epithelial dysplasia are precursor lesions to gastric adenocarcinoma, but are not readily detectable clinically, radiographically, or endoscopically. A noninvasive method of precursor detection would require the ability to distinguish precursor lesion...

BACKGROUND/AIMS Gastric epithelial dysplasia is considered a precancerous lesion with a variable clinical course. There is disagreement, however, regarding histology-based diagnoses, which has led to confusion in choosing a therapeutic plan. New objective markers are needed to determine which lesions progress to true malignancy. We measured LINE-1 methylation levels, which have been reported to...

AIMS To assess the role of human papillomavirus in the pathogenesis of adenocarcinoma in situ, endocervical glandular dysplasia (a presumed precursor of adenocarcinoma) and endocervical glandular epithelial giant cell change. METHODS Viral detection was carried out using an in situ hybridisation technique on paraffin wax sections. Biotinylated probes for human papillomavirus types 6/11, 16/18...

Conventional oral cancer screening examinations can be enhanced by direct tissue fluorescence visualization. Early dysplastic lesions detected during screening examinations often are monitored for progression or changes in appearance. Aggressive surgical intervention usually is contraindicated for mild epithelial dysplasia. As epithelial dysplasia progresses from mild to severe, the likelihood ...