نتایج جستجو برای: epithelial cells of choroid plexus

تعداد نتایج: 21318226  

Journal: :Toxicology and applied pharmacology 1998
Q Zhao V Slavkovich W Zheng

Lead (Pb) exposure reportedly modulates PKC activity in brain endothelial preparations, which may underlie Pb-induced damage at the blood-brain barrier. Our previous work indicates that Pb accumulates in the choroid plexus and causes dysfunction of this blood-cerebrospinal fluid (CSF) barrier. The present studies were undertaken to test the hypothesis that Pb in the choroid plexus may alter PKC...

2015
Carlos Spuch Desireé Antequera Consuelo Pascual Soledad Abilleira María Blanco María José Moreno-Carretero Jesús Romero-López Tetsuya Ishida Jose Antonio Molina Alberto Villarejo Felix Bermejo-Pareja Eva Carro

Megalin or low-density lipoprotein receptor-related protein-2 is a member of the low-density lipoprotein receptor family, which has been linked to Alzheimer's disease (AD) by clearing brain amyloid β-peptide (Aβ) across the blood-cerebrospinal fluid barrier at the choroid plexus. Here, we found a soluble form of megalin secreted from choroid plexus epithelial cells. Soluble megalin levels were ...

2016
Fatih Keskin Fatih Erdi Bülent Kaya Hatice Toy

Choroid plexus papillomas (CPPs) are relatively rare neuroectodermal tumors that develop from choroid plexus epithelial cells and are usually restricted to the ventricles. Extraventricular CPPs are very unusual and can be difficult to diagnose and treat. A 50-year-old male patient was admitted to our clinic complaining of headache and visual deterioration. Neurological examination found no abno...

Journal: :The Journal of Biophysical and Biochemical Cytology 1959
Norman M. Case

Since the first light microscope descriptions of the choroid plexus by Faivre (1) and Luschka (2), numerous kinds of granules and vacuoles have been described as components of epithelial cells of the choroid plexus, such as slightly pigmented, os-miophilic granules (3), hyaline-like granules (4), and fuchsinophilic and basophilic granules (5). These observations were promptly interpreted as evi...

Journal: :Molecular pharmacology 2003
Sumio Ohtsuki Takuya Takizawa Hitomi Takanaga Nobuyuki Terasaki Takeo Kitazawa Masako Sasaki Takaaki Abe Ken-ichi Hosoya Tetsuya Terasaki

The cerebrospinal fluid-to-blood efflux transport of estrone-3-sulfate (E(1)S) via the blood-cerebrospinal fluid barrier (BCSFB) may play an important role in regulating E(1)S levels in the brain. Here, we investigated the efflux transport of E(1)S at the BCSFB using conditionally immortalized rat choroid plexus epithelial cells (TR-CSFB) and identified the responsible transporter. The [(3)H]E(...

Journal: :American journal of physiology. Cell physiology 2004
Tracey Speake Jonathan D Kibble Peter D Brown

The choroid plexuses secrete, and maintain the composition of, the cerebrospinal fluid. K+ channels play an important role in these processes. In this study the molecular identity and properties of the delayed-rectifying K+ (Kv) conductance in rat choroid plexus epithelial cells were investigated. Whole cell K+ currents were significantly reduced by 10 nM dendrotoxin-K and 1 nM margatoxin, whic...

جواد موسوی, بی بی زهرا, طهرانی پور, مریم, محمدی, سمیه,

Introduction: Diabetes mellitus is a metabolic disorder with systemic complications. Children of diabetic mothers are at risk of many disorders such as major and minor vascular injuries, retinopathy, and atherosclerosis. The present study aimed to investigate the effects of maternal diabetes on changes in choroid plexus volume and capillaries length in 15.5 day foetus. Methods: in this experi...

Journal: :Journal of neurochemistry 2004
Nathan S Teuscher Hong Shen Cathaleen Shu Jianming Xiang Richard F Keep David E Smith

PEPT2 is functionally active and localized to the apical membrane of rat choroid plexus epithelial cells. However, little is known about the transport mechanisms of endogenous neuropeptides in choroid plexus, and the role of PEPT2 in this process. In the present study, we examined the uptake kinetics of carnosine in rat choroid plexus primary cell cultures and choroid plexus whole tissue from w...

Journal: :Archives of pathology & laboratory medicine 2008
Purva Gopal John R Parker Robert Debski Joseph C Parker

Choroid plexus carcinoma is an uncommon neoplasm of the central nervous system most commonly found in the pediatric population. It is associated with a dismal prognosis, especially if incompletely resected. Accurate histopathologic diagnosis is imperative, and this neoplasm should always be included in the differential diagnosis of a papillary intraventricular tumor. Histopathologic features in...

Journal: :Infection and immunity 2004
Rüdiger A Adam Tobias Tenenbaum Peter Valentin-Weigand Maurice Laryea Bernd Schwahn Susanne Angelow Hans-Joachim Galla Walter Däubener Horst Schroten

The involvement of the choroid plexus in host defense during bacterial meningitis is unclear. Aiming to elucidate possible antibacterial mechanisms, we stimulated primary porcine choroid plexus epithelial cells (pCPEC) with proinflammatory cytokines and challenged them with various Streptococcus suis strains. In the supernatant of gamma interferon (IFN-gamma)-stimulated pCPEC, streptococcal gro...

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