epilepsy is one of the most common neuroinflammatory disorders that affect more than 50 million people worldwide. excessive electrical discharges in neurons following neural cell damage or loss leads to recurrent seizures, which are described as epilepsy. one of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (tle), which results from hippocampal sclerosis. cu...

objective the lennox-gastaut syndrome (lgs: the triad of intractable seizures of various types, a slow spike-wave pattern in eeg and mental retardation) is one of the most difficult epilepsy syndromes to treat. the aim of this study was to evaluate the efficacy and safety of zonisamide (zns) as add-on therapy in seizures of children with lgs. materials & methods in a quasi- experimental study, ...

abstract seizure disorders are the most common neurological illnesses in infants and children. presented is an 8 year old boy with nocturnal vomiting episodes, found to have eeg characteristics of early onset benign occipital epilepsy, better known as panayiotopoulos syndrome.

During the last decade, advances in genetic technology have led to an explosion of identification genes associated with epilepsy. A diagnosis for individual epilepsy can clarify and predict prognosis, treatment options, need screen additional clinical features. Next-generation sequencing has enabled simultaneous a large number DNA segments. Using this technology, group is organized into panel a...

Epilepsy is a common neurological disease with various seizure types, complicated etiologies, and unclear mechanisms. Its diagnosis mainly relies on clinical history, but an electroencephalogram also crucial auxiliary examination. Recently, brain imaging technology has gained increasing attention in the of epilepsy, conventional magnetic resonance can detect epileptic foci some patients epileps...

Epilepsy is a clinical syndrome caused by highly synchronized abnormal discharges of neurons in the brain. It common disease nervous system. The pathogenesis epilepsy has not been fully understood yet. main pathological changes after seizures are programmed neuronal death and glial proliferation. Autophagy catabolic process. Moderate autophagy critical to maintain homeostasis cell health, while...

background: epilepsy is the second common neurologic disorder. although many antiepileptic drugs have been formulated to control the seizures, but not all seizures have been controlled by them. uncontrolled epilepsy can actually reduce the patients’ quality of life. objectives: identifying the proportion of adult intractable epilepsy among epileptic patients in an area in the north east of iran...

Epilepsy is considered to be one of the most common and disabling diseases, yet we still do not have a sufficient understanding detailed pathophysiology this condition and, as well treatment rationale for much epilepsy. This article reviews clinical aspects epilepsy seizure intending provide physicians an insight into that might tractable scientific investigations. defined, diagnostic methods a...

Epilepsy is one of the most important diseases of nervous system that involves 0.5-1% of the population. In spite of new developments in antiepileptic drugs, between 20-30% of epileptic patients can not be controlled and even those who are controlled with antiepileptic drugs suffer from their adverse events. Epileptic patients have different challenges in relation to the disease and its medicat...