Background: Epigenetic modifications are involved in different cellular processes through regulating chromatin dynamics. histone methylation is an important modification that can be dynamically regulated by histone methyltransferase and histone demethylase enzymes. JMJD1A (also known as JHDM2A and KDM3A) is a histone demethylase specific for H3K9me2/me1. JMJD1A is a key epigenetic regulator tha...

Lately, a brand-new studies agenda emphasizing interactions between societal elements and wellness has emerged. The phrase social determinant of health fitness typically refers to any nonmedical element directly effecting health, including behaviors, knowledge, attitudes, values. Status is adversely strongly impacted throughout the life span by disadvantages. Epigenetic mechanisms are implicate...

alteration in methylation pattern of promoters is associated with tumorigenic events,(1, 2) and differentiation control,(3, 4) in several types of cells in humans.specific hypermethylation in promoter region of some genes exist in different types of neoplastic cells.(5) dna methylation indicates to the addition of a methyl moiety to the cytosine in a cpg dinucleotide. cpg dinucleotides tend to ...

saffron is the dried stigmas of crocus sativus l., a member of the iridaceae family which ispropagated by means of corms. corms are faced with many stresses in soil. therefore, it isimportant to reduce these stresses and improve the quantity of saffron production. biotic andabiotic stresses disrupt the metabolic balance of cells; thereby, resulting in accumulation ofreactive oxygen species (ros...

background ovarian cancer is the most common fatal gynecologic malignancy in women. the brca2 gene has a role in regulation of cell cycle during proliferation, differentiation and dna repair. changes in the methylation of brca2 may be an effective mechanism for ovarian cancer. objectives the aim of the present study was to evaluate the association between ovarian cancer and methylation status o...

Abstract Epigenetic genome engineering expands our capabilities from modifying the DNA sequence to controlling its regulation. It provides ability change epigenetic marks at defined genomic loci control gene expression without need for an intervention in genetic code. This short review touches on current approaches of editing with a focus long-term silencing.

background: epigenetic reprogramming of differentiated cells can modify somatic cells into pluripotential state. pluripotency can be induced in somatic cells by several approches. one of the easy ways to induce pluripotency is the exposure of the somatic cells to the embryonic stem cell (esc) extract. objective: the objective of this study was to increase the efficiency of reprogramming of gran...