Integrins play a critical role in the regulation of adhesion, migration, proliferation, and differentiation of cells. Because of the variety of the functions they play in the cell, they are necessary for the formation and maintenance of tissue structure integrity. The trove of data accumulated by researchers suggests that integrins participate in the morphogenesis of the epidermis and its appen...

Sulfur mustard or mustard gas has been widely used as a chemical weapon in the first world war and Iraq-Iran war. It causes acute and chronic complications in lungs, eyes and skin. In skin, mustard is toxic, mutagenic, and carcinogenic via alkylation of cellular proteins in enzymes, cell membranes, cytoplasm and particularly cell nucleus as well as in DNA components of the epidermis, dermis and...

The homeostasis of the epidermis and corneal epithelium is maintained by proliferation differentiation their corresponding stem cells, keratinocytes in basal layer epidermis, limbal cells limbus cornea. Keratinocytes are morphologically similar but distinct fates to support organ-specific functions. A potential disease mechanism underlying opacity acquiring cell non-transparent emphasizing impo...

plastic epidermis and in lesions of squamous cell carcinoma. The growth fraction in control unirradiated mice was also 100%. The duration of TV and S decreased progressively with induction and progression of the tumor. For normalappearing epidermis of irradiated mice and epidermis of control mice, TVand S were approximately 95 and 6.2 hr, respectively. With the induction of hyperplasia, TV and ...

Desmogleins are desmosomal cadherins that mediate cell-cell adhesion. In stratified squamous epithelia there are two major isoforms of desmoglein, 1 and 3, with different distributions in epidermis and mucous membrane. Since either desmoglein isoform alone can mediate adhesion, the reason for their differential distribution is not known. To address this issue, we engineered transgenic mice with...

objective: the aim of this study was to estimate the cheminformatics and qualitative structure-activity relationship (qsar) of cinnamaldehyde and eugenol. the effects of cinnamaldehyde and eugenol on the viability, doubling time and adipogenic or osteogenic differentiations of human adipose-derived mesenchymal stem cells (hascs) were also investigated.  materials and methods: qsar and toxicity ...

In skin penetration studies, HPLC-MS/MS analysis on extracts of heat-separated epidermis and dermis provides an estimate the amount drug penetrated. this study, MALDI-MSI enabled qualitative distribution endogenous molecules molecule, tofacitinib quantitative in epidermis. The delivery to was investigated a Franz diffusion cell using three different formulations (two oil-in-water creams, C1 C2 ...

During plant epidermal development, many cell types are generated fromprotodermal cells, a process requiringcomplex co-ordinationof cell division, growth, endoreduplication and the acquisition of differentiated cellular morphologies. Herewe show that theArabidopsis phytocalpain DEFECTIVE KERNEL 1 (DEK1) promotes the differentiated epidermal state. Plants with reduced DEK1 activity produce cotyl...