نتایج جستجو برای: epiderm

تعداد نتایج: 71  

2013
Nicusor Iftimia R. Daniel Ferguson Mircea Mujat Ankit H. Patel Ellen Ziyi Zhang William Fox Milind Rajadhyaksha

A combined high-resolution reflectance confocal microscopy (RCM)/optical coherence tomography (OCT) instrument for assessing skin burn gravity has been built and tested. This instruments allows for visualizing skin intracellular details with submicron resolution in the RCM mode and morphological and birefringence modifications to depths on the order of 1.2 mm in the OCT mode. Preliminary testin...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2010
Stacey E Anderson Christina Umbright Rajendran Sellamuthu Kara Fluharty Michael Kashon Jennifer Franko Laurel G Jackson Victor J Johnson Pius Joseph

Although ortho-phthalaldehyde (OPA) has been suggested as an alternative to glutaraldehyde for the sterilization and disinfection of hospital equipment, the toxicity has not been thoroughly investigated. The purpose of these studies was to evaluate the irritancy and sensitization potential of OPA. The EpiDerm Skin Irritation Test was used to evaluate in vitro irritancy potential of OPA and glut...

Journal: :Journal of Investigative Dermatology 2022

Protein phosphatase 2A (PP2A) is a critical target to control cumulative oxidative stress and chronic inflammation during skin aging by reversible methylation of the C-terminal leucine PP2A catalytic subunit (PP2Ac). A novel, proprietary Activated-Grape Seed Extract (AGSE), enriched for PP2A-activating flavonoids, was recently developed, has demonstrated potent antioxidant anti-inflammatory act...

Journal: :Molecules 2017
Buket Demir Roy M Broughton Mingyu Qiao Tung-Shi Huang S D Worley

This work demonstrated the successful application of N-halamine technology for wound dressings rendered antimicrobial by facile and inexpensive processes. Four N-halamine compounds, which possess different functional groups and chemistry, were synthesized. The N-halamine compounds, which contained oxidative chlorine, the source of antimicrobial activity, were impregnated into or coated onto sta...

Journal: :Journal of cell science 2014
Parinya Noisa Carina Lund Kartiek Kanduri Riikka Lund Harri Lähdesmäki Riitta Lahesmaa Karolina Lundin Hataiwan Chokechuwattanalert Timo Otonkoski Timo Tuuri Taneli Raivio

Neural crest cells are specified at the border between the neural plate and the epiderm. They are capable of differentiating into various somatic cell types, including craniofacial and peripheral nerve tissues. Notch signaling plays important roles during neurogenesis; however, its function during human neural crest development is poorly understood. Here, we generated self-renewing premigratory...

2016
Mahima Manian Kumpal Madrasi Ayyappa Chaturvedula Ajay K. Banga

Effective topical therapy of cutaneous fungal diseases requires the delivery of the active agent to the target site in adequate concentrations to produce a pharmacological effect and inhibit the growth of the pathogen. In addition, it is important to determine the concentration of the drug in the skin in order to evaluate the subsequent efficacy and potential toxicity for topical formulations. ...

Journal: :Toxicology in vitro : an international journal published in association with BIBRA 2010
Kristina Kejlová Dagmar Jírová Hana Bendová Petr Gajdoš Hana Kolářová

The aim of this study, linked-up with a previous study on bergamot oils, was the evaluation of phototoxic potential of essential oils (orange, lemon and Litsea cubeba), used as cosmetic ingredients. The applied tiered testing strategy included chemical analysis of the substances (by means of capillary gas chromatography/mass spectrometry), in vitro 3T3 NRU phototoxicity test and EpiDerm™ skin p...

2014
K. E. Chapman A. D. Thomas J. W. Wills S. Pfuhler S. H. Doak G. J. S. Jenkins

Recent restrictions on the testing of cosmetic ingredients in animals have resulted in the need to test the genotoxic potential of chemicals exclusively in vitro prior to licensing. However, as current in vitro tests produce some misleading positive results, sole reliance on such tests could prevent some chemicals with safe or beneficial exposure levels from being marketed. The 3D human reconst...

ژورنال: Anatomical Sciences Journal 2003
Allameh, Abdol Amir, Asadi Sar Yazdi, Mohammad Hassan, KHajeh, Mohammad Reza, Mohammadi , Mostafa,

Purpose: The aim of this study was to evaluate the effect of age on the capacity of liver and epiderm of adult and weanging rats in transformation of Benzo (α) Pyrene. Materials and Methods: In a metabolic activiation assay system, cytochorome P-50 (from microsomal fraction) catalyses the formation of reactive epoxide of BaP which can then interact with exogenous DNA The capacity of cytochrome...

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