نتایج جستجو برای: ep2 subtype

تعداد نتایج: 56071  

Journal: :Cancer research 2005
You Me Sung Guobin He Susan M Fischer

The EP2 receptor for prostaglandin E2 (PGE2) is a membrane receptor that mediates at least part of the action of PGE2. It has been shown that EP2 plays a critical role in tumorigenesis in mouse mammary gland and colon. However, the possibility that the EP2 receptor is involved in the development of skin tumors was unknown. The purpose of this study was to investigate the role of the EP2 recepto...

Journal: :Anticancer research 2006
Li-Shu Wang Yi-Wen Huang Suling Liu Hsiang-Lin Chang Weiping Ye Sherry Shu Yasuro Sugimoto Julie A Funk Daniel D Smeaks Lawrence N Hill Young C Lin

BACKGROUND Conjugated linoleic acid (CLA), a naturally occurring linoleic acid isomer found in ruminant-produced foods, has the potential to serve as an effective chemopreventive nutriceutical factor for breast cancer prevention based upon previous published studies. There are several CLA isomers in ruminant-produced food products, among which t10,c12-CLA and c9,t11-CLA are more potent. Express...

2014
Na-Na Li Yu-Yin Xu Xiao-Lan Chen Ya-Ping Fan Jian-Hua Wu

The prostaglandin E2 receptor, EP2 (E-prostanoid 2), plays an important role in mice glomerular MCs (mesangial cells) damage induced by TGFβ1 (transforming growth factor-β1); however, the molecular mechanisms for this remain unknown. The present study examined the role of the EP2 signalling pathway in TGFβ1-induced MCs proliferation, ECM (extracellular matrix) accumulation and expression of PGE...

Journal: :Human reproduction 2007
S Battersby K J Sales A R Williams R A Anderson S Gardner H N Jabbour

BACKGROUND Prostaglandin E(2) (PGE(2)) has been shown to modulate angiogenesis and tumour progression via the E-series prostanoid-2 (EP2) receptor. Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration in seminal plasma. METHODS This study investigated fibroblast growth factor 2 (FGF2) mRNA expression and cell signalling in respons...

Journal: :Oncology letters 2017
Annika Gustafsson Asting Britt-Marie Iresjö Camilla Nilsberth Ulrika Smedh Kent Lundholm

Prostaglandin E2 (PGE2) is elevated in a variety of malignant tumors and has been shown to affect several hallmarks of cancer. Accordingly, the PGE2 receptor, E-prostanoid 2 (EP2), has been reported to be associated with patient survival and reduced tumor growth in EP2-knockout mice. Thus, the aim of the present study was to screen for major gene expression alterations in tumor tissue growing i...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Jenny U Johansson Suraj Pradhan Ludmila A Lokteva Nathaniel S Woodling Novie Ko Holden D Brown Qian Wang Christina Loh Egle Cekanaviciute Marion Buckwalter Amy B Manning-Bog Katrin I Andreasson

Prostaglandin E2 (PGE2), a potent lipid signaling molecule, modulates inflammatory responses through activation of downstream G-protein coupled EP(1-4) receptors. Here, we investigated the cell-specific in vivo function of PGE2 signaling through its E-prostanoid 2 (EP2) receptor in murine innate immune responses systemically and in the CNS. In vivo, systemic administration of lipopolysaccharide...

2015
Tetsuyuki Takahashi Hisanori Uehara Hirohisa Ogawa Hitomi Umemoto Yoshimi Bando Keisuke Izumi

Associations between growth factor receptor-mediated cell signaling and cancer cell growth have been previously characterized. Receptors for prostaglandin E2, such as EP2, and EP4, play roles in cancer growth, progression and invasion. Thus, we examined the interactions between EP2/EP4- and IGF-1R-mediated cellular signaling in human pancreatic cancer cells. Selective antagonists against EP2 an...

Journal: :Blood 2012
Zbigniew Zaslona Carlos H Serezani Katsuhide Okunishi David M Aronoff Marc Peters-Golden

Prostaglandin E(2) (PGE(2)) is a lipid mediator that acts by ligating 4 distinct G protein-coupled receptors, E prostanoid (EP) 1 to 4. Previous studies identified the importance of PGE(2) in regulating macrophage functions, but little is known about its effect on macrophage maturation. Macrophage maturation was studied in vitro in bone marrow cell cultures, and in vivo in a model of peritoniti...

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