In this study, the effect of phytic acid supplement on streptozotocin-induced diabetic rats was investigated. Diabetic rats were fed rodent chow with or without phytic acid supplementation for thirty days. Blood and organ samples were collected for assays. The average food intake was the highest and the body weight gain was the lowest in the group fed phytic acid supplement compared to the diab...

The effects of grain and carbohydrase enzyme supplementation were investigated on digestive physiology of chickens. A total of 625 one-day-old chicks (Ross 308) were randomly assigned to five treatments in a completely randomized design. Treatments included two different types of grains (wheat, and barley) with or without a multi-carbohydrase supplement. A corn-based diet was also considered to...

The activity of cytochrome p450 isozyme 3A4 (CYP3A4) enzyme and P-glycoprotein (P-gp) is modulated by grapefruit juice and herbal drugs. CYP3A4 is the major phase I drug metabolizing enzyme and P-gp is an ATP-dependent drug efflux pump that regulates the intestinal absorption of orally administered drugs. Honey is commonly consumed as a dietary supplement. However, its influence on human CY...

Culture A58365.1, NRRL 15098, identified as a new strain of Streptomyces chromofuscus, was found to produce two novel angiotensin converting enzyme (ACE) inhibitors, A58365A and A58365B. Fermentation medium studies afforded an increase in ACE inhibitor titers from less than 1 microgram/ml to greater than 20 micrograms/ml. Proline was the obligatory supplement for ACE inhibitor biosynthesis.

Objective: Exercise and herbs can possess synergistic effects to control diabetes side-effects. The purpose of the present study was to investigate the effects of high intensity interval training (HIIT) and curcumin supplement on activity levels of superoxide dismutase (SOD) and catalase of heart tissue in diabetic rats. Materials and Methods: Thirty-two male Wistar rats were randomly divi...

A previous survey for glucose-6-phosphate dehydrogenase (G6PD) deficiency among the Saudi Arab population residing along the Persian Gulf perimeter revealed a high frequency of the enzyme defect among subjects from oasis areas. The investigation reported was undertaken to supplement the previous study using a screening test with the same reliability as the conventional Motulsky brilliant cresyl...

Objective: It was reported exercise and herbal medicine can possess synergistic effects to control of diabetes complications. The purpose of the present study was investigation of the effects of high-intensity interval training (HIIT) and taking curcumin supplement on activity levels of GPX and MDA of heart tissue in diabetic rats. Materials and Methods: Thirty-two male Wistar rats were random...

Background: To clarify if a2-macroglobulin (a2M) has an antioxidative effect during the progression of intervertebral disc degeneration (IVDD). Methods: The content a2M and reactive oxygen species (ROS) were measured to compare mildly severely degenerated human nucleus pulposus (NP) tissue by immunohistochemistry, mass spectrometry, enzyme-linked immunosorbent assay (ELISA). Additionally, exoge...