T cells primed specifically for the envelope glycoprotein of Friend murine leukemia helper virus (F-MuLV) were prepared by immunizing mice with a recombinant vaccinia virus that expressed the entire env gene of F-MuLV. Significant proliferative responses of F-MuLV envelope-specific, H-2a/b T cells were observed when the T cells were stimulated with antigen-pulsed peritoneal exudate cells (PEC) ...

Natural language predicts viral escape Viral mutations that evade neutralizing antibodies, an occurrence known as escape, can occur and may impede the development of vaccines. To predict which lead to Hie et al. used a machine learning technique for natural processing with two components: grammar (or syntax) meaning semantics) (see Perspective by Kim Przytycka). Three different unsupervised mod...

AIDS is characterized by CD4+ T lymphocyte depletion, yet the mechanisms underlying this central aspect of HIV pathogenesis are still poorly understood. In this issue of the JCI, Espert et al. identify a mechanism by which the HIV envelope glycoprotein can induce death in uninfected CD4+ T cells (see the related article beginning on page 2161). The HIV envelope glycoprotein interacts with CXC c...