نتایج جستجو برای: envelope domain iii ediii

تعداد نتایج: 689457  

Journal: :Virology 2006

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Journal: :BMC Biotechnology 2007
Saima Khanam Pilankatta Rajendra Navin Khanna Sathyamangalam Swaminathan

BACKGROUND Dengue is a public health problem of global significance for which there is neither an effective antiviral therapy nor a preventive vaccine. It is a mosquito-borne viral disease, caused by dengue (DEN) viruses, which are members of the Flaviviridae family. There are four closely related serotypes, DEN-1, DEN-2, DEN-3 and DEN-4, each of which is capable of causing disease. As immunity...

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Journal: :Journal of virology 2002
David W C Beasley Alan D T Barrett

Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330...

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2015
Seema Zargar Tanveer A Wani SK Jain

Purpose: To identify protein targets in host (vero) cell since there is currently no therapy or a licensed tetravalent vaccine to combat all the four virus serotypes of dengue virus. Methods: The domain III of the dengue virus encoded envelope protein was expressed in pET28a expression vector and the purified recombinant protein was labeled with biotin without altering its immunogenicity. Vero ...

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Journal: :Journal of immunology 2009
Oren Hershkovitz Benyamin Rosental Lior Ann Rosenberg Martha Erika Navarro-Sanchez Sergey Jivov Alon Zilka Orly Gershoni-Yahalom Elodie Brient-Litzler Hugues Bedouelle Joanna W Ho Kerry S Campbell Bracha Rager-Zisman Philippe Despres Angel Porgador

Dengue virus (DV) and West Nile virus (WNV) have become a global concern due to their widespread distribution and their ability to cause a variety of human diseases. Antiviral immune defenses involve NK cells. In the present study, we investigated the interaction between NK cells and these two flaviviruses. We show that the NK-activating receptor NKp44 is involved in virally mediated NK activat...

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2017
Lázaro Gil Laura Lazo Iris Valdés Edith Suzarte Phuong Yen Rosa Ramírez Mayling Álvarez Le T Dung Karem Cobas Ernesto Marcos Yusleidi Pérez María G Guzmán Ngyen D Hien Gerardo Guillén Lisset Hermida

Tetra DIIIC is a vaccine candidate against dengue virus (DENV) composed by four chimeric proteins that fuse the domain III of the envelope protein of each virus to the corresponding capsid protein. Containing B- and T-cell epitopes, these proteins form aggregates after the incubation with an immunostimulatory oligodeoxynucleotide, and their tetravalent formulation induces neutralizing antibodie...

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Journal: :Journal of virology 2003
Cheng-Wen Lin Suh-Chin Wu

The envelope (E) protein of Japanese encephalitis virus (JEV) is associated with viral binding to cellular receptors, membrane fusion, and the induction of protective neutralizing-antibody responses in hosts. Most previous studies have not provided detailed molecular information about the spatial configuration of the functional epitopes on domain III of the E protein. Here site-directed mutagen...

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Journal: :Vaccines 2020

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Journal: :Chemical and Pharmaceutical Bulletin 2014

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Journal: :PLOS Pathogens 2019

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