Enterostatin (Ent) selectively suppresses the intake of dietary fat after peripheral and central administration. To further investigate the site of action of Ent, we compared the feeding responses to Ent injected intra-arterially near the celiac artery, into the carotid artery, or intravenously in rats adapted to a high-fat diet. After near-celiac arterial injection there was an immediate dose-...

Ashwani Sethi1 Deepika Sareen2 Sumit Mrig3 A.K.Agarwal4 1M.S.; Senior resident, Department of ENT; M.A.M.C. and associated L.N. Hospital 2M.B.B.S.; Junior resident, Department of ENT; M.A.M.C. and associated L.N.Hospital. 3M.B.B.S.; Junior resident, Department of ENT; M.A.M.C. and associated L.N.Hospital 4M.S.; Director Professor, Department of ENT &Dean, M.A.M.C. and associated L.N.Hospital Fr...

Three ent-trachylobane diterpenes have been isolated from the leaf exudates of Psiadia punctulata and characterised as 6alpha,17,19-ent-trachylobantriol; 2alpha,18,19-ent-trachylobantriol; and 2beta,6alpha,18,19-ent-trachylobantetraol. The structures were determined on the basis of spectroscopic evidence.

Feeding experiments with ent-kaurenoic acid (4), 15 alpha-hydroxy-ent-kaurenoic acid (5), 15 beta-hydroxy-ent-kaurenoic acid (6), and mixtures of 4 plus 5 and 4 plus 6 were conducted using the SG138 mutant of Gibberella fujikuroi, to gain information about the phenotype of this unique strain. The biotransformation of 5 gave 7 beta,15 alpha-dihydroxykaurenolide (9) and 7 beta,15 alpha-dihydroxy-...

Two new ent-kauren-19-oic acid derivatives, ent-14S*-hydroxykaur-16-en-19-oic acid and ent-14S*,17–dihydroxykaur-15-en-19-oic acid together with eleven known compounds entkaur-16-en-19-oic acid, ent-kaur-16-en-19-al, ent-12β-hydroxykaur-16-en-19-oic acid, ent12β-acetoxykaur-16-en-19-oic acid, 8R,13R-epoxylabd-14-ene, eudesm-4(15)-ene-1β,6αdiol, (–)-7-epivaleran-4-one, germacra-4(15),5E, 10(14)-...

Lin, Ling, George Bray, and David A. York. Enterostatin suppresses food intake in rats after near-celiac and intracarotid arterial injection. Am J Physiol Regulatory Integrative Comp Physiol 278: R1346–R1351, 2000.—Enterostatin (Ent) selectively suppresses the intake of dietary fat after peripheral and central administration. To further investigate the site of action of Ent, we compared the fee...

A copper-promoted C3-cyanation of both the free N-H and N-protected indoles by N,N,N',N'-tetramethyl-ethane-1,2-diamine (TMEDA) and ammonium is achieved. The iminium ion acts as the intermediate in this transformation, which is sequentially electrophilically attacked by indole and H2O followed by hydrolyzation to form the aldehyde. Then the reaction between the aldehyde and ammonium afforded ni...

Two ent-18-acetoxy-6-oxomanoyl oxides, epimers at C-13, have been prepared from ent-6alpha,8alpha,18-trihydroxylabda-13(16),14-diene (andalusol), isolated from Sideritis foetens, by means of several chemical pathways and a regioselective acylation with Candida cylindracea lipase (CCL). Biotransformation of these 13-epimeric ent-manoyl oxides by Fusarium moniliforme and Neurospora crassa produce...

Enterobactin (Ent), a prototypic bacterial siderophore, is modified by both the C-glucosyltransferase IroB and the macrolactone hydrolase IroE in pathogenic bacteria that contain the iroA cluster. To investigate the possible effects of glucosylation and macrolactone hydrolysis on the physical properties of Ent, the membrane affinities and iron acquisition rates of Ent and Ent-derived siderophor...

An efficient synthesis of ent-halimanolide 2 (15,16-epoxy-12-oxo-ent-halima- 5(10),13(16),14-trien-18,2beta-olide), from ent-halimic acid has been achieved, corroborating the structure of the natural compound and establishing its absolute configuration.