background: despite a high prevalence of endometriosis, there still exist many challenges in diagnosing the disease. this study aims to evaluate non-invasive and practical diagnostic methods by measuring serum and peritoneal fluid ca 125 levels in patients with endometriosis. a secondary aim is to determine the correlation between these markers with the stage of disease as well as the relations...

BACKGROUND The role of leptin in reproductive processes has received increasing attention. Because leptin has intrinsic angiogenic properties, may be induced by inflammatory cytokines and induces matrix metalloproteinases, we examined peritoneal fluid (PF) leptin concentrations in women with endometriosis. METHODS PF samples were collected from 60 women undergoing laparoscopy for endometriosi...

BACKGROUND Clinico-pathological characteristics and possible prognostic factors among women with epithelial ovarian carcinoma (EOC) with or without concurrent endometriosis were explored. METHOD We retrospectively identified 304 patients with EOC treated primarily at Peking Union Medical College Hospital with median follow-up time of 60 months. RESULTS Of 304 patients with EOC, concurrent e...

OBJECTIVE To generate and validate symptom-based models to predict endometriosis among symptomatic women prior to undergoing their first laparoscopy. DESIGN Prospective, observational, two-phase study, in which women completed a 25-item questionnaire prior to surgery. SETTING Nineteen hospitals in 13 countries. PATIENT(S) Symptomatic women (n = 1,396) scheduled for laparoscopy without a p...

OBJECTIVE To examine the effect of peritoneal fluid (PF) of patients with endometriosis on the cytoskeleton of metaphase II oocytes and correlate the results with the stage of endometriosis and the duration of infertility. DESIGN Prospective-controlled study. SETTING Center for reproductive medicine at a tertiary-care hospital. PATIENT(S) Women with endometriosis (n=23) and tubal ligation...

Transvaginal sonography (TVS) is now established as a first line imaging tool of choice for the preoperative assessment of endometriosis in women planning laparoscopy for surgical treatment of endometriosis.1,2 The evolution of TVS in the preoperative assessment of women with suspected endometriosis is a result of the technological advances in gynaecological ultrasound imaging tools and the eme...

Reliably diagnosing endometriosis traditionally requires surgery. To evaluate a possible non-surgical method, a case-control series of unexplained infertility patients undergoing diagnostic laparoscopy were scored by clinical criteria and reactivity to human carbonic anhydrase II by Western blotting. The CA II autoantibodies were found in none of the fertile controls, 38 percent of infertile co...

Although there is confirmed an association between endometriosis and infertility, precise standards of managements have not yet been established. Ablation of endometriotic lesions plus adhesiolysis in minimal to mild endometriosis is more effective than diagnostic laparoscopy alone in improving fertility. Suppression of ovarian function and hormonal treatment alone are not effective in improvin...

BACKGROUND The hypothesis is tested that there is a strong association between endometriosis and adenomyosis and that adenomyosis plays a role in causing infertility in women with endometriosis. METHODS. Magnetic resonance imaging of the uteri was performed in 160 women with and 67 women without endometriosis. The findings were correlated with the stage of the disease, the age of the women and ...

BACKGROUND Typically, endometriosis is diagnosed surgically by laparoscopy. CA-125 is the principal serum marker used in the diagnosis and management of late-stage endometriosis. The search for a body fluid marker of early stage disease has included studies of serum, peritoneal fluid (PF), and/or tissue levels of secretory proteins, cell adhesion molecules, cytokines, tumor necrosis and vascula...