Abstract Introduction/Objective Uterine leiomyosarcoma is a malignant neoplasm with three distinct histologic subtypes: spindle, epithelioid, and myxoid. Distinguishing from mesenchymal uterine neoplasms such as endometrial stromal sarcoma can be challenging they may exhibit similar histology immunohistochemical profile. In cases, molecular studies help achieve the definitive diagnosis. It has ...

OBJECTIVE Hox genes encode DNA transcription regulatory proteins that contain a conserved 61 amino acid protein called the homeodomain. Although best known for their role in cellular differentiation during embryonic development, aberrant expression of these genes has been associated with hematologic and solid neoplasms. The purpose of this study was to determine the relative expression of HOXD1...

Placental polyp is retained placental tissue within the endometrial cavity, which forms a nidus for inflammation and bleeding. There are very few reported cases of the clinical placental polyp. Here, we report a case of 34-year-old G4L3Ab1 woman with the chief complaint of intermittent vaginal bleeding since her last normal vaginal delivery 3 months ago. Serum human chorionic gonadotropin (hCG)...

Myometrial infiltration represents a main clinical determinant of endometrial carcinomas (EC) presenting as aggressive high-grade deeply invasive neoplasms, substantially associated with risk of recurrence and death. The up-regulation of ETV5 transcription factor linked to the promotion of epithelial to mesenchymal transition is considered as a basic mechanism underlying the initial steps of EC...

Patients with breast cancer exhibit an increased risk in developing neoplasms of other organs. In case of endometrium, the increased risk might be due to tamoxifen adjuvant therapy and prior radiotherapy. Carcinosarcomas are rare uterine cancers and carry poor prognosis. We present a case of Malignant Mixed Mullerian Tumor (MMMT) of the uterus in a 46-year-old woman, after tamoxifen treatment a...

The administration of estrogens for gonadal dysgenesis is sometimes associated with the development of endometrial neoplasms. An approach which minimizes the inadvertent side effects while still providing the desired therapeutic effects may be to imitate the hormonal milieu of the normal menstruating woman. Oral administration of estradiol will not necessarily accomplish this, because of the in...

The present study aimed to investigate the feasibility of applying contrast-enhanced ultrasonography (CEUS) imaging technology for distinguishing between benign and malignant endometrial lesions, and to screen markers that could be correlated with the pathological results. In this study, endometrial diseases were diagnosed by biopsy under hysteroscopy and CEUS examinations. The intensity and ti...

Transgender is defined as an incongruence between the assigned at birth sex and experienced gender identity. The biological neither familiar nor acceptable to transgender people. Gender-affirming hormone treatment (GHT) a multidisciplinary approach aiming develop maintain physical characteristics of desirable sex. influence exogenous hormones on cancer pathogenesis development subject ceaseless...

OBJECTIVE Clear cell endometrial cancer (CCE) is an uncommon but important disease because of its aggressive behavior. Furthermore, prospective, randomized studies are either too difficult or impossible because of the small number of women affected. This review explores the differences between clear cell and endometrioid endometrial cancer. In addition, it uses available evidence to determine t...

The uterine corpus represents the most common site for tumour development in the female genital system. Uterine neoplasms are categorised as epithelial, mesenchymal, mixed epithelial-mesenchymal or trophoblastic tumours. In this study we employed a mouse genetic approach using the MuLE lentiviral gene regulatory system to functionally test the ability of ecotropic lentiviruses to model epitheli...