PURPOSE Recent studies have shown that 7% to 12% of endometrial cancers are ultramutated due to somatic mutation in the proofreading exonuclease domain of the DNA replicase POLE. Interestingly, these tumors have an excellent prognosis. In view of the emerging data linking mutation burden, immune response, and clinical outcome in cancer, we investigated whether POLE-mutant endometrial cancers sh...

Despite extensive research in the area of cow fertility, the extent to which the maternal immune system is modulated during pregnancy in cattle remains unclear. Therefore, the objective of the current study was to characterize the presence and response profile of B, T-helper (LTh), T- cytotoxic (LTc), gamma delta-T (γδT) and natural killer (NK) lymphocytes in terms of cell number, distribution ...

OBJECTIVE We analyzed the histologic and immunohistochemical changes in the endometrial leukocytic subpopulations to determine which of them are characteristic of chronic endometritis. RESULTS Endometrial biopsies from 25 cases of chronic endometritis and 35 controls were studied. Characteristic morphologic findings included the presence of a plasma cell infiltrate, and a prominent, albeit no...

The studies on removal of Vanadium were conducted using Granulated Activated Carbon (GAC) in combination with Chelating agents. Ethylene di-amine Tetra Acetic Acid (EDTA) and Nitrilo Tri Acetic Acid (NTA) at 25oC. The adsorption Efficiency was studied in the pH range of 2-8. The results reveals that Langmuir and Freundlich isotherms are followed during adsorption process with the chelating agen...

Large granular lymphocytes migrate in large numbers to the pregnant uteri of a wide variety of mammalian species (1). These cells, also known as granulated metrial gland cells in rodents and endometrial granulocytes in primates, will for the purposes of this review all be referred to as uterine (u)NK cells. uNK cells are bone marrow–derived leukocytes, but their immediate precursors may migrate...

Purpose: Recent studies have shown that 7% to 12% of endometrial cancers are ultramutated due to somatic mutation in the proofreading exonuclease domain of the DNA replicase POLE. Interestingly, these tumors have an excellent prognosis. In view of the emerging data linking mutation burden, immune response, and clinical outcome in cancer, we investigatedwhether POLE-mutant endometrial cancers sh...

A human monoclonal antibody termed HMST-1 was produced by fusing lymphocytes from segments of human pelvic lymph nodes from an endometrial cancer patient with murine myeloma cells. The epitope recognized by HMST-1 was determined to be lacto-series type 1 chain-containing glycosphingolipid (Gal beta 1-3GlcNAc beta 1-3Gal beta 1-4Glc beta 1-1Cer) by isolating the antigen from endometrial cancer c...

A human monoclonal antibody termed HMST-1 was produced by fusing lymphocytes from segments of human pelvic lymph nodes from an endometrial cancer patient with murine myeloma cells. The epitope recognized by HMST-1 was determined to be lacto-series type 1 chaincontaining glycosphingolipid (Gal/Sl-3GlcNAci81-3Gal|81-4Glc/SlICer) by isolating the antigen from endometrial cancer cell line SNG-II an...

Human thymocytes cultured in the presence of IL-2 and an irradiated B cell line became cytotoxic to K562 target cells. Thymocytes cultured alone or with only IL-2 exhibited almost no killing, but thymocytes cultured in the presence of stimulator cells alone exhibited low levels of cytotoxic activity. Removal of Fc gamma receptor-bearing cells from the activated thymocyte population almost compl...

Tumor infiltrating lymphocytes (TILs) were evaluated in many cancers like ovarian tumors, endometrial colon cancer and melanoma. Now there is increasing trend evaluating TILs breast cancer. gives the patients immune response to tumor. 100 cases of Modified radical mastectomy specimen chosen from surgical pathology records. The representative formalin fixed paraffin embedded tissue samples colle...