OBJECTIVE To evaluate the efficacy of cervical lidocaine gel in reducing patient discomfort during Pipelle endometrial sampling. MATERIALS AND METHODS From September 2012 to January 2013, 137 patients were evaluated with Pipelle endometrial biopsy. For group 1 (77 women), 2% lidocaine gel was applied to the cervical canal 3 min before endometrial sampling. For group 2 (60 women), a placebo ge...

BACKGROUND The purpose of this study was to investigate the endometrial safety of an oral contraceptive containing estradiol valerate/dienogest (E(2)V/DNG) administered as an estrogen step-down and progestogen step-up regimen in women of reproductive age (18-50 years), using histological assessment of endometrial biopsy samples. METHODS Endometrial biopsies were taken in a subset of healthy w...

Inactivation of PTEN tumor suppressor gene is common in endometrial carcinoma and its precursor, atypical endometrial hyperplasia (EH). We compared PTEN expression via immunohistochemistry in endometrial biopsies diagnosed as EH in 138 cases, who were diagnosed with EH and then endometrial carcinoma at least 1 year later (median, 6 years), and 241 individually matched controls, who were diagnos...

background: genital tuberculosis (gtb) is an important cause of female infertility, especially in developing countries. the positive results of polymerase chain reaction (pcr) in endometrial gtb in the absence of tubal damage raise the possibility of the detection of sub-clinical or latent disease, with doubtful benefits of treatment. objective: to evaluate the mycobacterium tuberculosis infect...

Aim: To determine frequency of positive endometrial biopsies in pre and post menopausal patients with abnormal uterine bleeding for detection of endometrial carcinoma. Methods: This Cross-sectional study was conducted at Gynecological outpatient department Nishtar Hospital Multan from January 2013 to December 2013. Pre and post-menopausal women between 3570 years with abnormal uterine bleeding ...

Objective. The main objective of the study was to determine the reliability of the Cornier’ pipelle endometrial biopsy in determining endometrial cancer, and the comparison of this with the gold standard method, dilatation and curettage. Materials and methods. A number of 105 patients with indication of endometrial biopsy were included in this study. Initially the Cornier’ pipelle endometrial b...

OBJECTIVE We investigated the features of endometrial hyperplasia with concurrent endometrial cancer that had been diagnosed by endometrial sampling. Further, we attempted to identify an accurate differential diagnostic method. METHODS We retrospectively studied 125 patients who underwent a diagnostic endometrial biopsy or were diagnosed after the surgical treatment of other gynecological les...

BACKGROUND Abnormal uterine bleeding is one of the most frequent problems in life of an adult female. Uterine curettage or biopsy remains a preferred sampling procedure for diagnosis of the endometrial pathology. The objective of this study was to compare the sensitivity, specificity, positive and negative predictive value of endometrial curettage. PATIENTS AND METHODS This validation study w...