نتایج جستجو برای: endolysin

تعداد نتایج: 320  

Journal: :Applied and environmental microbiology 2010
Shumin Hu Jian Kong Wentao Kong Tingting Guo Mingjie Ji

The endolysin Lyb5, from Lactobacillus fermentum temperate bacteriophage phiPYB5, showed a broad lytic spectrum against Gram-positive as well as Gram-negative bacteria. Sequence analysis revealed that the C terminus of the endolysin Lyb5 (Ly5C) contained three putative lysin motif (LysM) repeat regions, implying that Ly5C was involved in bacterial cell wall binding. To investigate the potential...

2016
Yumei Li Qiang Li Yamei Li Juan Gao Xiangyu Fan

We report here the draft genome sequence of Paenibacillus polymyxa KF-1, which exhibits excellent antimicrobial activity. It encodes the synthase of bacitracin, kalimantacin, bacillomycin, iturin, fusaricidin, tridecaptin, and pelgipeptin and biosynthetic pathways of antiviral curldan and levan polysaccharides. Also, a novel prophage is involved in this genome that contains endolysin-encoding g...

Journal: : 2023

Antimicrobial resistance is considered by WHO as one of the most important threats to public health in twenty-first century. According forecasts, 2025, many first-line antimicrobials will lose their effectiveness and «post-antibiotic era» begin. Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. representatives ...

2015
Ana Oliveira Marta Leite Leon D. Kluskens Sílvio B. Santos Luís D. R. Melo Joana Azeredo

The Data Availability statement for this paper is incorrect. The correct statement is: All relevant data are within the paper and its Supporting Information files, except the aminoacidic sequence of the endolysin, which is available in RefSeq, accession number YP_008320357.1. Copyright: © 2015 Oliveira et al. This is an open access article distributed under the terms of the Creative Commons Att...

2017
Soo Youn Jun In Jin Jang Seonghae Yoon Kyungho Jang Kyung-Sang Yu Joo Youn Cho Moon-Woo Seong Gi Mo Jung Seong Jun Yoon Sang Hyeon Kang

This study was a phase 1, single-center, randomized, double-blind, placebo-controlled, single-dosing, and dose-escalating study of intravenous SAL200. It is a new candidate drug for the treatment of antibiotic-resistant staphylococcal infections based on a recombinant form of the phage endolysin SAL-1. The study evaluated the pharmacokinetics, pharmacodynamics, and tolerance among healthy male ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Jill S Dewey Christos G Savva Rebecca L White Stanislav Vitha Andreas Holzenburg Ry Young

Holins are small phage-encoded proteins that accumulate harmlessly in the cytoplasmic membrane during the infection cycle until suddenly, at an allele-specific time, triggering to form lethal lesions, or "holes." In the phages lambda and T4, the holes have been shown to be large enough to allow release of prefolded active endolysin from the cytoplasm, which results in destruction of the cell wa...

Journal: :Journal of general microbiology 1974
S Ogata M Hongo

Growing Clostridium saccharoperbutylacetonicum was lysed by sodium ion concentrations above 0.1 M (maximum effect at 0.3 M). The rate of lysis depended on the age of the culture. The most rapid lysis occurred in organisms from logarithmically growing cultures which were incubated for 3 to 5 h; organisms from stationary phase cultures were completely resistant to Na+-induced lysis. Sodium ionind...

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