Introduction Certain individuals and families seem to be unusually prone to develop organ-specific autoimmune disorders. The conditions which appear most closely associated are thyroid disease (Hashimoto's thyroiditis, thyrotoxicosis or primary hypothyroidism), Addison's disease, hypoparathyroidism and pernicious anaemia. A number of other conditions may also be associated including diabetes me...

Research on black representation in Congress emphasizes the material gains associated with black office holding over the intangible goods associated with citizens’ ability to identify racially with their legislators. This article considers the effect of descriptive representation on the relationships among citizens, legislators, and the Congress. With data from the 1980–1998 ANES, I show that w...

INTRODUCTION Autosomal dominant chronic mucocutaneous candidiasis (CMC) without endocrinopathy (OMIM 114580) is a well-described entity. The associations recorded with this disorder to date are intercellular adhesion molecule-1 (ICAM-1) deficiency and hyper-immunoglobulin E syndrome. CLINICAL PICTURE We report a new association in a family (mother and nonidentical twin sons) where acne rosace...

Polyneuropathy, organomegaly, endocrinopathy, M proteins, and skin changes (POEMS) syndrome is a rare variant of plasma cell disorders with multiple systemic manifestations. A 50-year-old female patient presented with progressive weakness in her upper and lower limbs; tingling, numbness and burning in her feet; polyneuropathy (demyelinating in the majority of cases of POEMS syndrome); monoclona...