The cellular composition and relative frequency of the occurrence of pancreatic endocrine cells were studied immunohistochemically in a primitive eutherian and arboreal folivore, the three-toed sloth, since previous histochemical and ultrastructural studies on the endocrine pancreas of the sloth have detected only a single islet cell type, the A cell. In the sloth pancreas, four types of endocr...

Neurogenin3(+) (Ngn3(+)) progenitor cells in the developing pancreas give rise to five endocrine cell types secreting insulin, glucagon, somatostatin, pancreatic polypeptide and ghrelin. Gastrin is a hormone produced primarily by G-cells in the stomach, where it functions to stimulate acid secretion by gastric parietal cells. Gastrin is expressed in the embryonic pancreas and is common in islet...

this paper is a statistical and analytical review of endocrine glands disorders, seen in the department of pathology, tehran university medical school, and is based on approximately 40,000 surgical specimens and 2,500 autopsy cases. of 42,500 combined routine surgical and autopsy cases reviewed, we had 2,556 cases of endocrine disorders of which there: thyroid 1,125 cases, ovary 970, testis 268...

Histological, immunocytochemical and immunofluorescence methods were employed to study the intestine and endocrine pancreas of the elephant. The histological findings were in line with those in monogastric mammals. In the mucosa of intestine, endocrine cells were immunoreactive to somatostatin, gastrin, CCK, GIP, secretin, motilin, glucagon and NPY. Nerve cells immunoreactive to somatostatin, s...

Nesidioblastosis pancreas was used as an immunogen in BALB/c-mice to generate monoclonal antibodies against structures of human islet cells. Seven clones were selected by screening 311 growing hybridomas for reactivity with the rat insulinoma cell line, RIN m5F, and with cryostat sections from human pancreas. None of the selected clones reacted with pancreatic hormones or endocrine-specific pep...

INTRODUCTION Pancreatic tumors usually display either a ductal, an acinar or an endocrine differentiation. Mixed exocrine and endocrine pancreatic tumors are extremely rare. There have been a few reports of the rare entity of mixed acinar-endocrine carcinoma of the pancreas, where the endocrine cells represent more than 30% of the tumor. We herein describe a case of such a pancreatic tumor in a...

Endocrine and exocrine pancreas tissues are both derived from the posterior foregut endoderm, however, the interdependence of these two cell types during their formation is not well understood. In this study, we generated mutant mice, in which the exocrine tissue is hypoplastic, in order to reveal a possible requirement for exocrine pancreas tissue in endocrine development and/or function. Sinc...

This short review presents the recent breakthroughts in our understanding of the important steps controlling pancreas morphogenesis and differentiation, and on the transcription factors regulating pancreas organogenesis and islet cell differentiation and involved in the specification of the beta and alpha cell lineages. All these studies should permit a comprehensive view of the full genetic pr...

-Aminobutyric acid (GABA) is a principal nonpeptidal neurotransmitter with a well-characterized role as an inhibitor of neuronal firing in the CNS (Cherubini et al., 1991; Thomas-Reetz and De Camilli, 1994). GABA is also found in other tissues, such as the endocrine pancreas (Thomas-Reetz and De Camilli, 1994). In the neuron, GABA is synthesized in close proximity to synaptic vesicles, it is pr...