Efficient near-infrared circularly polarised luminescence (CPL) between 1400 and 1600 nm of four enantiomer pairs homo- heteroleptic complexes have been successfully measured.

We investigated the stereoselective inhibition of growth and ergosterol biosynthesis by SCH39304 in the pathogenic fungus Cryptococcus neoformans obtained from four AIDS patients who failed fluconazole therapy and compared the results to those obtained with a wild-type strain. For all strains, the MICs of the RR isomer were approximately half those of the racemate, with the SS enantiomer showin...

The relationship between chiral inversion and stereoselective amino acid conjugation of a new nonsteroidal anti-inflammatory agent, R, S-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (R,S-MTPPA) was investigated in rats and dogs. Only the S-enantiomer was found in plasma after oral administration of S-MTPPA to both species. In contrast, the R- and S-enantiomers were both detected after the dos...

Title: Enantiomer-specific isotope analysis (ESIA) of D-and L-alanine: nitrogen isotopic hetero-and homogeneity by microbial process and chemical process. Abstract Nitrogen isotopic hetero-and homogeneity of D-α-alanine and L-α-alanine were investigated in microbial processes in the domain Bacteria and in chemical processes in symmetric organic synthesis. D-alanine is an enantiomer that is phys...

A potentiometric sensor for enantiomers has been prepared with no chiral additives, only cobaltabisdicarbollide and the protonated enantiomer.

A glandular secretion of the civet cat, (2S,6S)-(6-methyltetrahydropyran-2-yl)acetic acid 1 and its enantiomer, were synthesized from the yeast-reduction product and recovered substrate from yeast reduction.

Single crystal X-ray diffraction has been used as one of the common methods for the unambiguous determination of the absolute stereostructure of chiral molecules. However, this method is limited to molecules containing heavy atoms or to molecules with the possibility of functionalization with heavy elements or chiral internal references. Herein, we report the determination of the absolute stere...

The beta-D-enantiomer of FDOC (2',3'-dideoxy-5-fluoro-oxacytidine) exhibits potent anti-HIV-1 activity. It was obtained in optically pure form by employing a tandem kinetic resolution/chiral salt crystallization protocol. In addition, conditions were developed that allowed the unwanted butyrate ester of the L-enantiomer of FDOC to be racemized. This material could then be recycled in future res...

To evaluate and quantify Irinotecan (R-enantiomer) / related compound D in hydrochloride trihydrate API, a high stereo-specific liquid chromatography technique was developed validated. The partition accomplished on ChiralpakIC-3 (150 x 4.6 mm 3µm) through mobile fragment comprising 0.1 % v/v Formic acid water acetonitrile with 1mL/min, 250C, 20µL, 50C 370 nmas flow rate, column temparture, inje...

The enantioselective local disposition of semotiadil (R-enantiomer) and levosemotiadil (S-enantiomer) in rat liver was investigated in the single-pass perfusion system containing 1% bovine serum albumin (BSA). After an instantaneous injection of semotiadil, levosemotiadil, or Evans Blue (a marker of BSA), each outflow time profile from the liver was analyzed by a two-compartment dispersion mode...