INTRODUCTION Narcoleptic patients may be at increased risk of prolonged emergence, postoperative hypersomnia, apneic episodes, and sleep paralysis after general anesthesia. Modafinil is the first-line treatment, however, the implication it has on general anesthesia is not clear. This report present 2 cases of narcoleptic patients medicated with modafinil that were submitted to total intravenous...

background: emergence delirium (ed) is a frequent postoperative complication in children. its prevalence is about 25-80% and is observed more commonly with rapid-acting volatile anesthetics than the older inhalation agents. methods: 30 patients aging between 2 to 8 years were included in this randomized double blind study. we compared the effect of combination of two anesthetic drugs, propofol-...

Background In pediatric general anesthesia, our goal should be quicker extubation to facilitate rapid turnover in the operating room without compromising on safety and quality of anesthesia. Although many studies have focused on improving safety and pursuing a higher quality of recovery, factors related to anesthesia emergence remain unclear. We must, therefore, identify factors that influence ...

A 34-month-old female patient who had a prior history of generalized tonic-clonic seizures had been diagnosed with the Lennox-Gastuat syndrome. She was scheduled for epiblepharon repairs in both lower lids under general anesthesia. Preoperatively, her tonic seizure was poorly controlled with antiepileptic drugs. General anesthesia with thiopental and isoflurane was provided and the intraoperati...

BACKGROUND Coughing during emergence from general anesthesia may be detrimental. Propofol is known to inhibit airway reflexes. We evaluated the incidence and severity of coughing in adults who received a subhypnotic dose of propofol at the end of sevoflurane-remifentanil anesthesia. METHODS Sixty patients, aged 18-65 years, undergoing elective nasal surgery under general anesthesia using sevo...

Delayed extubation occurs after isoflurane anesthesia, especially following prolonged surgical duration. We aimed to determine the arterial blood concentrations of isoflurane and the correlation with end-tidal concentrations for predicting emergence from general anesthesia.Thirty-four American Society of Anesthesiologists physical status class I-II gynecologic patients were included. General an...

Background: The mechanisms of emergence from general anesthesia remain to be elucidated. Recent studies indicate that the central histaminergic system plays a critical role in maintaining wakefulness. In addition, neural pathways regulate wake-sleep cycle are involved anesthesia. this study, we determined propofol using microinjections and single-unit recordings rats.

Introduction Though postoperative excitement has been a feature of general anesthesia since before the development of most of our modern inhalational anesthetics, the number of studies examining the incidence of postoperative agitation has increased exponentially since the introduction of the poorly soluble inhalation agents sevoflurane and desflurane into routine anesthesia practice. Eckenhoff...

BACKGROUND AND OBJECTIVES Emergence delirium is a distressing complication of the use of sevoflurane for general anesthesia. This study sought to determine the incidence of emergence delirium and risk factors in patients at a specialist pediatric hospital in Kingston, Jamaica. METHODS This was a cross-sectional, observational study including pediatric patients aged 3-10 years, ASA I and II, u...

The neural mechanisms through which the state of anesthesia arises and dissipates remain unknown. One common belief is that emergence from anesthesia is the inverse process of induction, brought about by elimination of anesthetic drugs from their CNS site(s) of action. Anesthetic-induced unconsciousness may result from specific interactions of anesthetics with the neural circuits regulating sle...