cancer is a leading cause of death worldwide. despite the availability of several chemotherapeutic drugs, there is still a great need for more efficient agents for a better management of cancer. in this contribution, a series of 11 dhps (4a, 4b & 7a-i) were synthesized and evaluated for their cytotoxic effect against mcf-7, ls180, and molt-4 cancer cell lines using mtt assay. synthesized 2,6-di...

a series of hydroxysemicarbazone derivatives of substituted diaryl ketones and acetophenones were synthesized and their structures were confirmed by analytical and spectroscopic methods including elemental analysis, infrared and nuclear magnetic resonance spectroscopy. the derivatives were prepared by a condensation reaction between n-hydroxysemicarbazide and substituted diaryl ketones or aceto...

the cytotoxicity of the biomaterials is a key issue that should be addressed prior to pre-clinical applications. this study was designed to evaluate and compare the cytotoxixity of two forms of bioactive glasses:nanopowder:andmicropowder. human hgf1-pi53 gingival fibroblast cells were used to evaluate the cytotoxicity of 0.5, 1, 1.5, 2, 5, 10, 15 and 20 mg/ml concentrations of the two bioactive...

background toxoplasmosis is a parasitic disease caused by the protozoan toxoplasma gondii. this parasite infects most of warm-blooded animals, including birds. turkeys are one of these animals which might be infected by this parasite. little is known about the prevalence of t. gondii in turkeys in iran. objectives the current study aimed to evaluate the rate of toxoplasma infection in turkeys i...

aim : we aimed to develop a multiplex pcr assay for specific detection of epec and ehec pathotypes based on specific marker genes. background : about 2.5 million infant’s morbidity in developing countries occurs by e.coli pathotypes because of diarrhea and intestinal diseases. the traditional phenotypic methods are time consuming and sometimes detection and differentiation of the pathotypes are...

use of different pesticides in the agriculture sector, in order to boost crop yield within a short time period and low labor, has been tremendously increased since the last decade. pesticide use has elevated crop yield but has produced a number of pronounced problems regarding environmental and health safety. the continuously deteriorating toxicological effects of these pesticides are not only ...

bordetella pertussis infects the respiratory tract of the human host and causes whooping cough in children. the nature of immunity against bordetella pertussis infection and disease is poorly understood. the aim of this study was to investigate cell mediated immunity in mice immunized with outer membrane component of cell wall, of b. pertussis. a group of mice were immunized with outer membrane...

a gradient reversed-phase high performance liquid chromatography (hplc) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (gnrh) antagonistic activity used in infertility treatment. the hplc method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ich guidelines. the chromatograph...

canine ehrlichiosis is a zoonotic rickettsial disease transmitted by ticks. in the present study, 198 companion dogs of different ages were examined for serum antibody detection against ehrlichia canis by means of immunochromatography assay. the dogs were selected among referred cases to veterinary hospital of shahid chamran university of ahvaz, southwestern iran from november 2008 to march 201...