Aim: To examine the utility of gene editing therapies for retinitis pigmentosa using Xenopus laevis carrying a mutation in Rhodopsin. Methods: were genetically modified CRISPR-Cas9 based methods and characterized by Sanger sequencing, dot blot, electroretinography, confocal microscopy. Results: We identified net 12 base pair deletion Rho.L gene. These animals have retinal degeneration that is a...

The focal cone electroretinogram (ERG) in monkey retina has been examined with a 3 deg pulse of laser light (544 and 633 nm) centered on a 25 deg steady white rod saturating field. The stimuli were viewed simultaneously through a slit lamp and corneal contact lens. Cone ERGs were studied at different eccentricities from the fovea and compared with full-field corneal and intraretinal ERGs. The c...

Purpose: to report a case of Siderosis Bulbi that attained a good postoperative visual outcome despite of non-recordable Electroretinogram.

Characteristics of the electroretinogram (ERG) produced by the essentially all rod eye of the rat are presented as functions of the number of quanta absorbed by each rod per stimulus flash. The ERG's were obtained with 1.5 msec. stimulus flashes and uniform illumination of the entire retina. Under these conditions, distortions in the ERG due to stray light are minimized, and the ERG more accura...

The pattern and diffuse flash electroretinograms were measured in 20 normal subjects and 40 diabetic patients who had either normal fundi or microaneurysms only. The amplitudes of the pattern electroretinogram were found to be similar in both normals and diabetics. In the case of the flash electroretinogram the diabetic patients showed a division into two main groups. One group was not dissimil...