Intracellular recordings, ATP and cytosolic calcium measurements from CA1 pyramidal cells in rat hippocampal slices were used to examine the mechanisms by which temperature alters hypoxic damage. Hypothermia (34 degrees C) preserved ATP (1.7 vs. 0.8 nM/mg) and improved electrophysiologic recovery of the CA1 neurons after hypoxia; 58% of the neurons subjected to 10 min of hypoxia (34 degrees C) ...

OBJECTIVES/HYPOTHESIS Existing intraoperative neuromonitoring (IONM) formats stimulate the recurrent laryngeal nerve (RLN) intermittently, exposing it to risk for injury in between stimulations. We report electrophysiologic parameters of continuous vagal monitoring, utilizing a novel real-time IONM format, and relate these parameters to intraoperative surgical maneuvers that delineate nascent a...

OBJECTIVES The goal of this study was to experimentally evaluate a novel noninvasive electrocardiographic imaging modality during intramural reentrant ventricular tachycardia (VT). BACKGROUND Myocardial infarction and subsequent remodeling produce abnormal electrophysiologic substrates capable of initiating and maintaining reentrant arrhythmias. Existing noninvasive electrocardiographic metho...

Case presentation A 79-year-old patient with a medical history of hypertension, diabetes, ischemic heart disease, and severe aortic stenosis underwent transaortic valve implantation (TAVI) of an Edwards SAPIEN S3 26 mm valve. The tracing in Figure 1 was recorded during electrophysiologic study performed 5 days after TAVI owing to the occurrence of a Figure 1 Tracing recorded during electrophysi...

To characterize the electrophysiologic properties of the ventricular arrhythmias occurring during reperfusion after acute coronary artery ligation, a study was undertaken to correlate the time course of appearance of such arrhythmias with specific electrophysiologic mechanisms. Thirty-seven dogs survived 30minute ligations of the left descending coronary artery, and all had either instantaneous...

Two leading groups of investigators are reporting differing conclusions regarding the value of electrophysiologic studies (EPS) in the Brugada syndrome. First, Brugada et al.1 reported that EPS has excellent accuracy for predicting outcome in the Brugada syndrome. Soon thereafter, however, Priori et al.2 concluded quite the opposite. Based on a study of 86 patients with Brugada syndrome who und...

procainamide on the electrophysiologic properties of the canine ventricular conducting system. J Pharmacol Exp Ther 185: 438, 1973 15. Singh BN, Vaughn-Williams EM: Effect of altering potassium concentrations on the action of lidocaine and diphenylhydantoin on rabbit atrial and ventricular muscle. Circ Res 29: 286, 1971 16. Danilo P, Hordof AJ, Rosen MR: Effects of disopyramide on electrophysio...