Introduction: pH is a physiological indicator of tumor lesions and other pathological abnormalities in soft tissues. MRI has shown tremendous potential for noninvasive in vivo pH measurements, though formidable challenges exist regarding sensitivity, accuracy and/or the need of a second pHunresponsive agent as control. Endogenous Chemical Exchange Saturation Transfer (CEST) and PARAmagnetic CES...

We describe a technique that permits broad-band, field-dependent ferromagnetic and electron paramagnetic resonance absorption measurements that is applicable to thin films and patterned micro-/nanostructured arrays and is based on a wire-wound meanderline approach. Techniques to prepare meanderlines and perform microwave measurements are described along with some demonstrations involving an ele...

Changes are induced in the electron spin resonance signal amplitude and microwave power saturation of the naturally occurring free radical in melanin by bound paramagnetic ions. The changes serve as experimental observables in competition experiments between diamagnetic and paramagnetic metal ions for melanin binding sites and between melanin and ethylenediaminetetraacetic acid for paramagnetic...

This perspective discusses the ways that advanced paramagnetic resonance techniques, namely electron-nuclear double resonance (ENDOR) and electron spin-echo envelope modulation (ESEEM) spectroscopies, can help us understand how metal ions function in biological systems.

The electron paramagnetic resonance (EPR) characteristics of wild type Chiamydomonas reinhardtii are compared with these of a mutant strain (ac-206) which lacks cytochrome 553. The steady-state signals I and II are similar but differ in their responses to light of long and short wavelengths, reflecting the fact that the electron transport chain linking photosystems I and II is interrupted. The ...

Dispersed detonation nanodiamonds have been studied by continuous-wave (CW) and pulse EPR techniques. The spectrum of bulk radicals (g = 2.0025 ± 0.0002, a Lorentz line shape with ΔHpp = 0.95 ± 0.05 mT) dominated in CW EPR and prevented to record spectra from other paramagnetic species. The pulse EPR spectrum was the superposition of the distorted P1-center spectrum with parameters (g = 2.0025,...

E.p.r. is a spectroscopic technique that probes the environment of a paramagnetic centre by defining tlie size and shape of the magnetic moment produced by the unpaired electron. and by characterizing any magnetic fields which might be produced by the parent molecule in the vicinity of the paramagnetic centre. In the context of our interests, these unpaired electrons are found either in selecte...

Studies of the effect of substitution with 170 on the e.p.r. spectra at 9 and 35 GHz of Mo(V) in the phosphate complex of sulphite oxidase are reported. Substitution of '7O-enriched water for normal water, for samples of the enzymes reduced by sulphite in the presence of normal phosphate, produced no detectable effect on the e.p.r. signal. If phosphate substituted with 170 was used, coupling du...