This work is concerned with multiscale analysis of nano-reinforced heterogeneous materials. Such materials exhibit surface effects that are typically taken into account through interface models in mean-field homogenization theories. However, both experiments and numerical simulations demonstrate the existence a perturbed area at boundary between inclusion matrix phase. modeled as an interphase ...

This study investigates the effectiveness of the antinociceptive effects of diclofenac, an NSAID, on the nociceptive behavior of morphine-treated rats on formalin test.Rats were treated with morphine-containing drinking water for twenty one days, which induced morphine dependence. The antinociceptive effects of 8, 16, and 32 mg/kg doses of diclofenac were then evaluated and compared with distil...

Polymer-clay nano-composite materials, in which nano-meter thick layers of clay dispersed in polymer matrix, have generally higher mechanical properties than normal polymeric materials. A new three-dimensional unit cell model has been developed for modeling three constituent phases including inclusion, interphase and matrix. The total elastic modulus of nano-composite is evaluated.  Numerical r...

this study investigates the effectiveness of the antinociceptive effects of diclofenac, an nsaid, on the nociceptive behavior of morphine-treated rats on formalin test.rats were treated with morphine-containing drinking water for twenty one days, which induced morphine dependence. the antinociceptive effects of 8, 16, and 32 mg/kg doses of diclofenac were then evaluated and compared with distil...

A fiber’s efficiency in a short-fiber composite can be accurately solved by shear-lag methods, which can account for fiber geometry, an imperfect interface (or interphase), and extend to low volume fractions. Such an analysis was used to evaluate the aspect ratio requirements for singlewalled nanotubes (SWNT) in a polymeric composite and contrast it to conventional fibers. The aspect ratio requ...

Polymer-clay nano-composite materials, in which nano-meter thick layers of clay dispersed in polymer matrix, have generally higher mechanical properties than normal polymeric materials. A new three-dimensional unit cell model has been developed for modeling three constituent phases including inclusion, interphase and matrix. The total elastic modulus of nano-composite is evaluated.  Numerical r...

Characterizing the link between small-scale chromatin structure and large-scale chromosome folding during interphase is a prerequisite for understanding transcription. Yet, this link remains poorly investigated. Here, we introduce a simple biophysical model where interphase chromosomes are described in terms of the folding of chromatin sequences composed of alternating blocks of fibers with dif...

The spindle pole body (SPB) is the equivalent of the centrosome in fission yeast. In vivo it nucleates microtubules (MTs) during mitosis, but, unlike animal centrosomes, does not act as a microtubule organizing center (MTOC) during interphase. We have studied the MT-nucleating activity of SPBs in vitro and have found that SPBs in permeabilized cells retain in vivo characteristics. SPBs in cells...

Introduction: Some evidence demonstrates endogenous inhibitory pathways of pain involved in the interphase (phase between early and later phase) of the formalin test. We previously showed that swimming stress modulates the pain-related behaviors during the interphase of the formalin test. In this study, we evaluated the role of the endogenous opioid system in modulating nociceptive responses of...