The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. Although stimulation of the Fas/TNFR receptor family triggers a canonical ‘extrinsic’ apoptosis pathway, we demonstrated that in the absence of intracellular apoptotic signaling it is capable of activating a common nonapoptotic death pathway, w...

Great smiles have harmony, symmetry, and a broadness consistent with the individual’s facial form, morphology, and balance. Smiles communicate, are expressive, and especially beautiful when full. People do not perceive narrow arch smiles to be appealing. A proportional smile fills the lip embrasures and eliminates black triangles. We see this as beauty in nature, and such symmetry is preferred ...

A 37-year-old man with symptoms of cardiovascular disease applied to our hospital. Seven years ago, he had undergone combined kidney and pancreas transplantation. Afterwards, 4 years ago, his renal transplantation was repeated because of rejection. Coronary artery angiography revealed two-vessel coronary artery stenosis. We performed coronary artery bypass grafting to treat the coronary artery ...

Human activities have more than doubled inputs of nitrogen (N) to terrestrial ecosystems worldwide (1). Until recently, most of this increase was focused in the developed regions of the world. With fertilizer consumption (2), fossil-fuel emissions (3), and biomass burning (4) rapidly increasing in less developed regions, sources and distribution of anthropogenic N now occur globally (5), as doe...

We consider the optimum north-south elongation for the Millimeter Array A con guration and interferometric arrays in general. The optimum elongation depends primarily on the observational requirements of the array, with a very weak dependance on the latitude. Assuming that the Millimeter Array A con guration will be used primarily for long integrations, we nd that the optimum north-south axis r...

In the 1998 general election, Minnesota had a voter turnout of 60 percent in a nonpresidential year. While this was also the highest turnout in the nation, a significant number of Minnesotans still did not exercise their right to vote. In fact, 1.4 million eligible voters of the state did not vote and 119 million people did not vote nationwide, a 36 percent participation rate. It is not surpris...