Background Neonatal sepsis is one of the most critical illness in neonates that is responsible for a great proportion of morbidity and mortality in neonates so early diagnosis and identification of high risk cases is a challenging aim of our study. The purpose of this study was to investigate the prognostic value of red cell distribution width (RDW), in neonatal sepsis at the time of admission ...

background objective: to evaluate the utility of specific cut-off values for c- reactive protein (crp) and immature-to-total neutrophil ratio (i/t) as screening tests for meningitis in culture negative early onset sepsis (eos). materials and methods retrospective chart review of 97 newborns with culture negative sepsis who had lumbar puncture performed as part of the sepsis evaluation in a leve...

Background: Early detection of neonatal sepsis and categorization of patients based on clinical severity is not yet effectively achieved. Some hematological parameters are used to formulate a hematological scoring system (HSS) and a modified hematological scoring system (MHSS) to diagnose neonatal sepsis. A promising biomarker: Presepsin, or Soluble Cluster of Differentiation 14 SubType (sCD14-...

Background: Neonatal sepsis is a life-threatening disease with an incidence of 1 to 10 per 1000 live births and a mortality rate of 15% to 50%. The clinical signs are non-specific and indistinguishable from those caused by a variety of neonatal noninfectious disorders. Objective: The aim of this study was to determine the importance of CD64 expression (FcgRI), a neutrophil surface marker, in ea...

Background Neonatal sepsis is one of the major causes of neonatal morbidity and mortality globally. Its incidence varies from 1 to 4 cases per 1,000 live births in developed countries. The burden of the problem occurs in the developing world while most confirmation is derived from developed countries. This study is aimed to assess the prevalence of neonatal sepsi...

Introduction: Infections are one of the main causes of death during childhood. Epidemiologic studies in Iran showed that the incidence of neonatal sepsis was 1.8% in 1995. Moreover, the incidence of neonatal meningitis is 0.2 to 0.4 in per 1,000 live births. The aim of this study was to determine the necessity of lumbar puncture (LP) in early neonatal sepsis. Methods: In a retrospective study, ...

background: neonatal sepsis is a major cause of mortality and morbidity, especially in developing countries. the goal of the present study was to determine the bacterial etiology and antibiotic sensitivity patterns of neonatal sepsis.   methods: this cross sectional study was conducted on 208 neonates admitted with clinically suspected sepsis over a period of 30 months. sepsis was divided into ...

OBJECTIVE The purpose of this study was to investigate intracellular redistribution of muscarinic cholinergic receptor (m2AChR) and the roles of receptor phosphorylation and gene transcription as underlying mechanisms in the rat heart during different phases of sepsis. METHODS Sepsis was induced by cecal ligation and puncture (CLP). The density of m2AChR in the sarcolemmal and light vesicle f...