Muscle fructose-1,6-bisphosphatase (FBPase), which catalyzes the hydrolysis of fructose-1,6-bisphosphate (F1,6BP) to fructose-6-phosphate (F6P) and inorganic phosphate, regulates glucose homeostasis by controlling glyconeogenic pathway. FBPase requires divalent cations, such as Mg2+, Mn2+, or Zn2+, for its catalytic activity; however, calcium ions inhibit muscle isoform interrupting movement lo...

The title compound, C17H15N3O2, is a monoclinic polymorph (P21/c with Z' = 1) of the previously reported triclinic (P-1 with Z' = 2) form [Gajera et al. (2013 ▸). Acta Cryst. E69, o736-o737]. The mol-ecule in the monoclinic polymorph features a central pyrazolyl ring with an N-bound p-tolyl group and a C-bound 1,3-benzodioxolyl fused-ring system on either side of the C atom bearing the amino gr...

The clinical diagnosis of overactive bladder (OAB) greatly varies and is based on subjective symptoms. A more objective method to diagnose and assess therapeutic outcome in OAB patients, especially for health care providers not trained in urology, needs to be found. Evidence has shown that urinary proteins such as nerve growth factor (NGF) and prostaglandin E2 levels increase in patients with O...

August 9, 2016 Circulation. 2016;134:e32–e69. DOI: 10.1161/CIR.0000000000000426 e32 Robert L. Page II, PharmD, MSPH, FAHA, Chair Cindy L. O’Bryant, PharmD Davy Cheng, MD, MSc Tristan J. Dow, MD Bonnie Ky, MD, MSCE C. Michael Stein, MB ChB, FAHA Anne P. Spencer, PharmD Robin J. Trupp, PhD, ACNP-BC, FAHA JoAnn Lindenfeld, MD, FAHA, Co-Chair On behalf of the American Heart Association Clinical Pha...

250 Urology Annals | Jul Sep 2014 | Vol 6 | Issue 3 9. Godlewski J, Maslowski Z, Tenderenda M. Primary osteosarcoma of the urinary bladder. C E J Urol 2009;62:37-8. 10. Akoluk A, Barazani Y, Slova D, Shah S, Tareen B. Carcinosarcoma of the bladder: case report and review of the literature. Can Urol Assoc J 2011;5:E69-73. 11. Chitiyo ME. Primary osteogenic sarcoma of the urinary bladder. J Patho...

The interaction of the eukaryotic translation initiation factor eIF4E with the initiation factor eIF4G recruits the 40S ribosomal particle to the 5' end of mRNAs, facilitates scanning to the AUG start codon, and is crucial for eukaryotic translation of nearly all genes. Efficient recruitment of the 40S particle is particularly important for translation of mRNAs encoding oncoproteins and growth-...

The emergence of eye-specific axonal projections to the dorsal lateral geniculate nucleus (dLGN) is a well established model system for exploring the mechanisms underlying afferent targeting during development. Using modern tract tracing methods, we examined the development of this feature in the macaque, an Old World Primate with a visual system similar to that of humans. Cholera toxin beta fr...

HOLLANDER, DANIEL, ELENA RIM, AND K. S. MURALIDHARA. Vitm2in K, intestind absorption in ViVO: influence of’ hninal contents on transport. Am. J. Physiol. 232(l): E69E74, 1977 or Am. J. Physiol.: Endocrinol. Metab. Gastrointest. Physiol. l(1): E69-74, 1977. -Intestinal absorption of [:3H]phylloquinone was investigated in the unanesthetized rat by the use of a technique of recirculating perfused ...

Motivated by the high public employment, and the public wage premia observed in Europe, a Real-Business-Cycle model, calibrated to German data (1970-2007), is set up with a richer government spending side, and an endogenous private-public sector labor choice. To illustrate the effects of fiscal policy, two regimes are compared and contrasted to one another exogenous vs. optimal (Ramsey) policy ...

Background: Bone erosion is a common manifestation of sinus fungus ball (SFB) on CT imaging, however, the relationship between CT imaging and clinical features of SFB with bone erosion were not clear. Purpose: To evaluate the CT imaging and clinical features of sinus fungus ball with bone erosion and to explore the possible factors underlying its formation. Material and methods: The clinical da...