نتایج جستجو برای: e2fs
تعداد نتایج: 164 فیلتر نتایج به سال:
The E2F family of transcription factors (E2Fs) plays an important role in the regulation of cell proliferation and apoptosis and includes 6 structurally related E2F proteins (E2F1 through 6). E2Fs function as heterodimers with members of the DP family (DP-1 and DP-2) to transactivate or repress gene expression and play important roles in regulating both cell proliferation and antiproliferative ...
E2F6 is believed to repress E2F-responsive genes and therefore serve a role in cell cycle regulation. Analysis of the human E2F6 promoter region revealed the presence of two putative E2F binding sites, both of which were found to be functionally critical because deletion or mutations of these sites abolished promoter activity. Ectopic expression of E2F1 protein was found to increase E2F6 mRNA l...
The E2F1, E2F2, and E2F3a transcriptional activators control proliferation. However, how the E2F activators regulate mitosis to maintain genomic integrity is unclear. Centrosome amplification (CA) and unregulated spindle assembly checkpoint (SAC) are major generators of aneuploidy and chromosome instability (CIN) in cancer. Previously, we showed that overexpression of single E2F activators indu...
Decreased BRCA1 expression in the absence of genetic mutation is observed frequently in sporadic cancers of the breast and other sites, although little is known regarding the mechanisms by which the expression of this gene can be repressed. Here, we show that activating and repressive E2Fs simultaneously bind the BRCA1 promoter at two adjacent E2F sites in vivo, and that hypoxia induces a dynam...
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