Dysplastic nevi were generally recognized, thanks to the contributions of Clark et al. in 1978. These lesions were described in a familial context, which was called the 'B-K mole syndrome'. However, it is worth noting that this was not the first time that these nevi had been described in the literature. If we look back in history, we can find that in 1820, Norris had already described some very...

Vol. 26 No. 4, 2014 547 Received June 4, 2013, Revised September 9, 2013, Accepted for publication September 13, 2013 Corresponding author: Seok-Jong Lee, Department of Dermatology, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-gu, Daegu 700-721, Korea. Tel: 82-53-420-5838, Fax: 82-53-426-0770, E-mail: [email protected] This is an Open Access article distributed under the terms...

Dr. Alfred T. Lane (Stanford University) organized the sixteenth annual meeting of the Society for Pediatric Dermatology, held in Wiliiamsburg, Virgitiia. The seventh annual Sidney Hurwitz Lecture was delivered by Dr. Rona M. MacKie (University of Glasgow) on "Melanoma: Risk Factors in Dysplastic Nevus Syndrome." President Anne Lucky (Cincinnati, Ohio) welcomed the society members to Wiliiamsbu...

moved owing to a clinical suspicion of malignancy, we collected the clinical differential diagnoses for all pigmented lesions biopsied. We defined clinically suspect lesions as those for which the study dermatologist’s differential diagnosis indicated melanoma and/or dysplastic nevus on the pathology requisition form. In this way, lesions removed for cosmetic purposes were excluded from the BMR...

Of 66 specimens from benign melanocytic nevi, including common acquired and congenital nevi, Spitz tumors (epithelioid cell nevi), and melanocytic nevi with dysplasia, 57 could be grown in tissue culture. The cultured cells were identified as melanocytes by the presence of premelanosomes and melanosomes. Cells from 28 of 32 nevus cultures grew in an anchorage-independent way in soft agar with a...

We previously reported a favorable histologic response of dysplastic nevi to topical tretinoin in three patients. To investigate the anticancer and cancer preventive effects of retinoids we have examined the effect of systemic isotretinoin on dysplastic nevi. After confirmatory baseline biopsies, eleven patients with the dysplastic nevus syndrome were treated with oral isotretinoin, 40 mg twice...

BACKGROUND Atypical lentiginous nevus (of the elderly) is a peculiar form of dysplastic nevus. Clinically, this condition can resemble malignant melanoma and histologically, it has a lentiginous pattern with variable degrees of atypia and an absence of dermal nests. These features may lead to an erroneous diagnosis of lentigo maligna melanoma or lentiginous melanoma. MATERIAL AND METHODS We r...

I have read—in sufficient detail I believe—the article by Morales-Callaghan et al1 on atypical melanocytic nevi without actually finding a definition of typical melanocytic nevus. If there are atypical cases of such nevi, it is to be supposed that they differ in some way from typical, and by extension habitual or common, ones. In addition, according to Table 1 of the aforementioned article, of ...

Gross and microscopic criteria are morphologic and thus subjectivity abounds for the pathologist in the diagnosis of benign and malignant melanocytic proliferations [1]. The state-of-the-art criteria, often touted to be definitive, delineates between benign and malignant conditions clinically and histopathologically. This issue becomes murky, however, when the same criteria, on occasion, are pr...