dysplastic hematopoiesis

نتایج جستجو برای: dysplastic hematopoiesis

تعداد نتایج: 13958 فیلتر نتایج به سال:

Hematopoiesis

Journal: :Journal of Medical Humanities 2018

Correlation of the plasma level of insulin-like growth factor-1 with the number of aberrant crypt foci in male individuals.

Journal: :Molecular medicine reports 2009

Hirokazu Takahashi Tetsuji Takayama Kunihiro Hosono Kyoko Yoneda Hiroki Endo Yuichi Nozaki Koji Fujita Masato Yoneda Masahiko Inamori Yasunobu Abe Noritoshi Kobayashi Hiroyuki Kirikoshi Kensuke Kubota Satoru Saito Hitoshi Nakagama Atsushi Nakajima

In human subjects, aberrant crypt foci (ACF) can be classified as dysplastic or non-dysplastic using magnifying colonoscopy. Dysplastic ACF are thought to be a biomarker for the risk of colorectal cancer (CRC). Hyperinsulinemia and insulin-like growth factor-1 (IGF-1) have also been reported to be associated with an increased risk of CRC. To clarify this association, we investigated the relatio...

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Identification of molecular alterations in gastrointestinal carcinomas and dysplastic hamartomas in Peutz-Jeghers syndrome.

Journal: :Carcinogenesis 2013

Susanne E Korsse Katharina Biermann G Johan A Offerhaus Anja Wagner Evelien Dekker Elisabeth M H Mathus-Vliegen Ernst J Kuipers Monique E van Leerdam Wendy van Veelen

Peutz-Jeghers syndrome (PJS) is caused by mutations in the LKB1 gene. It is characterized by gastrointestinal polyposis and an increased cancer risk, mainly in the gastrointestinal tract. Mechanisms of PJS-associated carcinogenesis are unclear. We investigated the involvement of candidate genes and molecular pathways in PJS-associated gastrointestinal cancers and dysplastic hamartomas. Cases we...

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Protein Kinase R as Mediator of the Effects of Interferon (IFN) γ and Tumor Necrosis Factor (TNF) α on Normal and Dysplastic Hematopoiesis

Journal: :Journal of Biological Chemistry 2011

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Combined Biological and Modeling Approach of Hematopoiesis: From Native to Stressed Erythropoiesis

Journal: :Social Science Research Network 2021

We developed here a new mathematical modelling approach which reconciliates native and stress hematopoiesis, focused on hematopoietic stem progenitor compartments. first proposed an erythropoiesis model leaning minimum of 6 cell-amplification compartments, able to reproduce erythropoiesis. A phenylhydrazine-induced hemolytic was next applied, and in vivo data were used estimate parameters throu...

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Three-dimensional distribution of acetabular cartilage thickness in patients with hip dysplasia: a fully automated computational analysis of MR imaging.

Journal: :Osteoarthritis and cartilage 2004

Takashi Nishii Nobuhiko Sugano Yoshinobu Sato Hisashi Tanaka Hidenobu Miki Hideki Yoshikawa

OBJECTIVE The aim of this study was to evaluate three-dimensional (3D) distribution of acetabular articular cartilage thickness in patients with hip dysplasia using in vivo magnetic resonance (MR) imaging, and to compare cartilage thickness distribution between normal and dysplastic hips. DESIGN Forty-five dysplastic hips without joint space narrowing on radiographs and 13 normal hips underwe...

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The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations.

Journal: :The Journal of clinical investigation 1996

P J Winyard R A Risdon V R Sams G R Dressler A S Woolf

Human dysplastic kidneys are developmental aberrations which are responsible for many of the very young children with chronic renal failure. They contain poorly differentiated metanephric cells in addition to metaplastic elements. We recently demonstrated that apoptosis was prominent in undifferentiated cells around dysplastic tubules (Winyard, P.J.D., J. Nauta, D.S. Lirenman, P. Hardman, V.R. ...

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Expression of CD34 in cirrhotic liver--reliance to dedifferentiation.

Journal: :Vojnosanitetski pregled 2010

Jasmina Gligorijević Biljana Djordjević Aleksandar Petrović Aleksandra Radirević Simonida Stojanović

BACKGROUND/AIM The vascular supply of dysplastic nodules (DN) is altered compared with surrounding cirrhotic nodules. Dysplastic nodules contain unpaired arteries which are isolated arteries unaccompained by bille ducts. In adition, capillarization or neovascularization is evident on CD34 and CD31 staining. The investigation of angiogenic profile of regenerative, dysplastic and nodules of hepat...

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Effect of oral isotretinoin on dysplastic nevi.

Journal: :Journal of the American Academy of Dermatology 1989

L Edwards F Meyskens N Levine

We previously reported a favorable histologic response of dysplastic nevi to topical tretinoin in three patients. To investigate the anticancer and cancer preventive effects of retinoids we have examined the effect of systemic isotretinoin on dysplastic nevi. After confirmatory baseline biopsies, eleven patients with the dysplastic nevus syndrome were treated with oral isotretinoin, 40 mg twice...

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A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes

2015

Gege Feng Robert Peter Gale Wen Cui Wenyu Cai Gang Huang Zefeng Xu Tiejun Qin Yue Zhang Bing Li Liwei Fang Hongli Zhang Lijuan Pan Naibo Hu Shiqiang Qu Jingya Wang Yajuan Cui Zhijian Xiao

BACKGROUND Dys-megakaryopoiesis is defined as ≥10 % of dysplastic megakaryocytes in bone marrow smears by the World Health Organization. However, concordance rates for dysplastic megakaryocytes between different observers is low and, consequently, evaluation of dysmegakaryopoiesis is also often discordant. RESULTS We performed CD41 immune staining and proposed a systematic classification of d...

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