نتایج جستجو برای: dyskinesias
تعداد نتایج: 912 فیلتر نتایج به سال:
Levodopa-induced dyskinesias are a common complication of long-term therapy in Parkinson's disease. Although both pre- and post-synaptic mechanisms seem to be implicated in their development, the precise physiopathology of these disabling involuntary movements remains to be fully elucidated. Abnormalities in glutamate transmission (over expression and phosphorylation of N-methyl-D-aspartate rec...
Following a period of stable response to dopaminergic medication (the “honeymoon” period), Parkinson’s disease (PD) patients gradually develop two progressive clinical phenomena requiring changes in the clinical management: motor fluctuations and dyskinesias. These two phenomena are intrinsically interconnected, but often require opposite treatment attitudes, because increases of dopaminergic t...
Since the 1980 s, when cell transplantation into the brain as a cure for Parkinson's disease hit the headlines, several patients with Parkinson's disease have received transplantation of cells from aborted fetuses with the aim of replacing the dopamine cells destroyed by the disease. The results in human studies were unpredictable and raised controversy. Some patients showed remarkable improvem...
The effect of sodium valproate 1200 mg daily on the disability of Parkinsonism and on levodopa-induced dyskinesia was assessed in a double-blind crossover trial with matched placebo in 12 patients with Parkinson's disease. No objective change in the severity of Parkinsonism or dyskinesias was noted. However, six out of nine patients who completed the trial noted a slight to moderate improvement...
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