نتایج جستجو برای: dysbiosis

تعداد نتایج: 3277  

2016
Hanneke Borgdorff Stuart D. Armstrong Hanne L. P. Tytgat Dong Xia Gilles F. Ndayisaba Jonathan M. Wastling Janneke H. H. M. van de Wijgert

BACKGROUND A Lactobacillus-dominated cervicovaginal microbiota (VMB) protects women from adverse reproductive health outcomes, but the role of L. iners in the VMB is poorly understood. Our aim was to explore the association between the cervicovaginal L. iners and L. crispatus proteomes and VMB composition. METHODS The vaginal proteomes of 50 Rwandan women at high HIV risk, grouped into four V...

2015
Nidhi M Sagar Ian A Cree James A Covington Ramesh P Arasaradnam

Background. There has been an increasing interest in the use of volatile organic compounds (VOCs) as potential surrogate markers of gut dysbiosis in gastrointestinal disease. Gut dysbiosis occurs when pathological imbalances in gut bacterial colonies precipitate disease and has been linked to the dysmetabolism of bile acids (BA) in the gut. BA metabolites as a result of microbial transformation...

2018
D Pagliari A Saviano E E Newton M L Serricchio A A Dal Lago A Gasbarrini R Cianci

Gut microbiota is key to the development and modulation of the mucosal immune system. It plays a central role in several physiological functions, in the modulation of inflammatory signaling and in the protection against infections. In healthy states, there is a perfect balance between commensal and pathogens, and microbiota and the immune system interact to maintain gut homeostasis. The alterat...

2017
Kimberley Lau Varun Srivatsav Ayesha Rizwan Andrew Nashed Rui Liu Rui Shen Mahmood Akhtar

The human gut is heavily colonized by a community of microbiota, primarily bacteria, that exists in a symbiotic relationship with the host and plays a critical role in maintaining host homeostasis. The consumption of a high-fat (HF) diet has been shown to induce gut dysbiosis and reduce intestinal integrity. Recent studies have revealed that dysbiosis contributes to the progression of cardiovas...

Journal: :Brain, Behavior, and Immunity 2016
Esther E. Fröhlich Aitak Farzi Raphaela Mayerhofer Florian Reichmann Angela Jačan Bernhard Wagner Erwin Zinser Natalie Bordag Christoph Magnes Eleonore Fröhlich Karl Kashofer Gregor Gorkiewicz Peter Holzer

Emerging evidence indicates that disruption of the gut microbial community (dysbiosis) impairs mental health. Germ-free mice and antibiotic-induced gut dysbiosis are two approaches to establish causality in gut microbiota-brain relationships. However, both models have limitations, as germ-free mice display alterations in blood-brain barrier and brain ultrastructure and antibiotics may act direc...

2016
Hiroko Nagao-Kitamoto Andrew B. Shreiner Merritt G. Gillilland Sho Kitamoto Chiharu Ishii Akiyoshi Hirayama Peter Kuffa Mohamad El-Zaatari Helmut Grasberger Anna M. Seekatz Peter D.R. Higgins Vincent B. Young Shinji Fukuda John Y. Kao Nobuhiko Kamada

BACKGROUND & AIMS Gut dysbiosis is closely involved in the pathogenesis of inflammatory bowel disease (IBD). However, it remains unclear whether IBD-associated gut dysbiosis contributes to disease pathogenesis or is merely secondary to intestinal inflammation. We established a humanized gnotobiotic (hGB) mouse system to assess the functional role of gut dysbiosis associated with 2 types of IBD:...

Journal: :Parkinsonism & related disorders 2015
Erica Cassani Michela Barichella Raffaella Cancello Ferruccio Cavanna Laura Iorio Emanuele Cereda Carlotta Bolliri Paola Zampella Maria Francesca Bianchi Benvenuto Cestaro Gianni Pezzoli

INTRODUCTION Changes in the composition of gut microflora have been associated with an increase in chronic diseases. Indican urinary concentration is one of the most common and easily assessable markers of intestinal dysbiosis. Little information is available on intestinal dysbiosis in Parkinson's disease (PD). We decided to investigate indican urinary concentrations in a cohort of PD patients....

Journal: :Journal of Perinatology 2020

Journal: :The Korean Journal of Obesity 2015

Journal: :JCI insight 2017
Chathur Acharya Sinem Esra Sahingur Jasmohan S Bajaj

Cirrhosis is a prevalent cause of morbidity and mortality, especially for those at an advanced decompensated stage. Cirrhosis development and progression involves several important interorgan communications, and recently, the gut microbiome has been implicated in pathophysiology of the disease. Dysbiosis, defined as a pathological change in the microbiome, has a variable effect on the compensat...

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