The effects of d-tubocurarine (dTC) on nicotinic synapses on sympathetic B and C neurons in the bullfrog were compared by recording trains of postganglionic compound action potentials (CAPs) at 0.5-20 Hz. Block by dTC was strongly use dependent in that the IC50 shifted almost 10-fold with increasing stimulus frequency. Maximum sensitivity to dTC occurred at 5 Hz in the B system and at 20 Hz in ...

PURPOSE/OBJECTIVES To obtain information about the knowledge and attitudes of oncology nurse practitioners (ONPs) concerning the effect of direct-to-consumer (DTC) advertising of prescription medications on prescribing patterns. DESIGN Exploratory survey. SETTING Oncology Nursing Society Nurse Practitioner Special Interest Group members in the United States. SAMPLE 221 of 376 ONPs complet...

The rotational symmetry of the Caenorhabditis elegans gonad arms is generated by the symmetrical migration of two distal tip cells (DTCs), located on the anterior and posterior ends of the gonad primordium. Mutations that cause asymmetrical migration of the two DTCs were isolated. All seven mutations were recessive and assigned to six different complementation groups. vab-3(k121) and vab-3(k143...

Serum thyroglobulin (Tg) is the main post-operative tumor biomarker for patients with differentiated thyroid cancer (DTC). However, the presence of thyroglobulin antibodies (TgAb) can interfere with Tg level and invalidate the test. In this study, we aimed to investigate the predicative value of midkine (MK) as a cancer biomarker for DTC patients with positive TgAb before the first 131I therapy...

PURPOSE Men with apparently localized prostate cancer often relapse years after radical prostatectomy. We sought to determine if epithelial-like cells identified from bone marrow in patients after radical prostatectomy, commonly called disseminated tumor cells (DTC), were associated with biochemical recurrence. EXPERIMENTAL DESIGN We obtained bone marrow aspirates from 569 men prior to radica...

BACKGROUND Patients with differentiated thyroid carcinoma (DTC) have a favorable prognosis after treatment with thyroidectomy, radioiodine, and TSH suppression. However, treatment is associated with long-term cardiovascular toxicity. The aim of this study was to evaluate whether there is an increased risk of atrial fibrillation (AF) in DTC patients and whether AF occurrence is related to DTC tr...

( ) ABSTRACT: The industrial and sanitary use of dithiocarbamates DTCs is on the rise, and the synthesis of new derivatives has increased the field of their application. Both positive and negative pharmacological and toxicological effects have been documented for DTCs. The development and application of new DTCs must be accompanied by the study of their toxicity, beginning with the performance ...

INTRODUCTION Recently, we demonstrated that digestive tract cancer (DTC) is associated with reduced fibrin clot permeability and impaired fibrinolysis. AIM We investigated determinants of fibrinolysis in DTC patients. MATERIAL AND METHODS In 44 consecutive patients with DTC and 47 controls matched for age, sex, and cardiovascular risk, we evaluated fibrinolysis proteins, platelet activation...

BACKGROUND Gene expression profiles were determined to demonstrate heterogeneity of viable disseminated tumor cells (DTC) in the blood of breast cancer patients. PATIENTS AND METHODS All patients (n = 48) suffered from metastatic disease (M1) and were treated with chemotherapy and/or Herceptin, respectively. Blood samples were analyzed by a DTC detection assay consisting of immunomagnetic tum...