Depolarization-induced suppression of inhibition (DSI) is an endocannabinoid-mediated short-term plasticity mechanism that couples postsynaptic Ca2+ rises to decreased presynaptic GABA release. Whether the gain of this retrograde synaptic mechanism is subject to long-term modulation by glutamatergic excitatory inputs is not known. Here, we demonstrate that activity-dependent long-term DSI poten...

OBJECTIVE To investigate the agreement between conventional colposcopic impression, dynamic spectral imaging (DSI) colposcopy and histology, for human papillomavirus type 16-positive (HPV16(+)) and non-16 high-risk (hr) HPV(+) women. DESIGN Prospective, comparative, multicentre clinical trial. SETTING Three colposcopy clinics in the Netherlands. POPULATION Women (n = 177) aged 18 years or...

Recent studies have clarified that endogenous cannabinoids (endocannabinoids) are released from depolarized postsynaptic neurons in a Ca(2+)-dependent manner and act retrogradely on presynaptic cannabinoid receptors to suppress inhibitory or excitatory neurotransmitter release. This type of modulation has been found in the hippocampus and cerebellum and was called depolarization-induced suppres...

This thesis presents the development of a prototype publication service for I2-DSI project. The Internet2 Distributed Storage Infrastructure (I2-DSI) project is developing an open architecture for scalable, robust middleware that will enable wide-area replication services for the research and education communities. In the current phase, the project has a wide-area testbed of six large storage s...

The reorientation away from drugs of abuse and toward social interaction is a highly desirable but as yet elusive goal in the therapy of substance dependence. We could previously show that cocaine preferring Sprague-Dawley rats which engaged in only four 15 min episodes of dyadic social interaction (DSI) did not reacquire and reexpress cocaine conditioned place preference (CPP) after a single c...

Here we report that a serotonergic neuron evokes two distinct neuromodulatory actions with different state, timing, and firing pattern dependencies. These neuromodulatory actions may have important behavioral functions. In the mollusc, Tritonia diomedea, EPSCs evoked by ventral swim interneuron B (VSI) exhibited intrinsic plasticity; after a spike train, EPSC amplitude increased from a basal st...

Neuromodulation is often thought to have a static, gain-setting function in neural circuits. Here we report a counter example: the neuromodulatory effect of a serotonergic neuron is dependent on the interval between its spikes and those of the neuron being modulated. The serotonergic dorsal swim interneurons (DSIs) are members of the escape swim central pattern generator (CPG) in the mollusk Tr...

Based on the modern spectrum estimation theory and wavelet packet analysis (WPA), a new method is proposed for suppressing discrete spectral interference (DSI) within partial discharge (PD) signal. Firstly, the frequencies of DSI are determined based on the FFT of measured signal. Then, a model of DSI could be assumed and its parameters, such as amplitude and phase can be calculated by using th...

The dynamic strength index (DSI), often calculated as the ratio of countermovement jump (CMJ) propulsion peak force to isometric mid-thigh pull (IMTP) peak force, is said to inform whether ballistic or maximal strength training is warranted for a given athlete. CMJ propulsion peak force is highly influenced by jump strategy, however, which is not highlighted by the DSI alone. This study aimed t...

In comparison with conventional diffusion tensor imaging (DTI) technique, diffusion spectrum imaging (DSI) allows for delineating crossing and touching fibers in the brain and has been explored in clinical and preclinical studies. Non-human primates (NHPs) resemble most aspects of human and are widely employed in various neuroscience researches and pharmaceutical development. In the present stu...