objective:  unaccustomed and intense eccentric exercise is a common cause of delayed-onset muscle soreness (doms). there are multiple remedies for the treatment of doms, but its clinical and laboratory pieces of evidence are scarce. currently, the treatments proposed for doms are numerous and include pharmaceuticals, herbal remedies, stretching, massage, nutritional supplements, and other alter...

background indomethacin is a nsaid (non-steroidal anti-inflammatory drug) that is used in treatment of pain and inflammatory. immediate and sustained release products of this drug have side effects, so a proper replacement is needed. use of the medicine via topical and cutaneous routs has advantages such as avoiding side effects on gastrointestinal; and supplying an amount of medicine in plasma...

Motivation: The use of multiple drugs, termed polypharmacy, is common to treat patients with complex diseases or co-existing medical conditions. However, a major consequence of polypharmacy is a much higher risk of adverse side effects for the patient. Polypharmacy side effects emerge because of drug-drug interactions, in which activity of one drug may change, favorably or unfavorably, if taken...