introduction: acute leukemia covers a broad spectrum of hematological clonal diseases originating from the malignant transformation of stem cells. current chemotherapeutic methods result in an incomplete response to primary regimens in 30-40% of cases. methods: 20 patients who had been diagnosed with acute leukemia and who had displayed defined criteria in order to enter our study, were assesse...

Four human immunodeficiency virus type 1 (HIV-1) treatment-naïve Thai patients began antiretrovival therapy with a triple drug regimen -zidovudine plus lamivudine plus indinavir; this regimen was modified at week 20 of therapy because of drug toxicity. The virus in all patients was suppressed to lower than 400 copies/ml while they were taking the triple antiretroviral drug regimen. However, sup...

We read with interest the article by Velayutham and colleagues, reporting on shorter regimens for newly diagnosed pulmonary tuberculosis [1]. Shortening duration of treatment is an unmet research need [2]. In this regard, trial et al. commendable. Nevertheless, it has certain limitations. While authors claim that regimen a high cure rate acceptable recurrence rate, we have two main concerns reg...

BACKGROUND Treatment failure (TF) and adverse drug reactions (ADRs) are the main indications for antiretroviral therapy (ART) regimen change. Identification of factors influencing regimen change and subsequent health outcomes of patients after regimen change is essential in providing a sustainable and effective antiretroviral roll-out campaign. AIM To confirm the factors that influence antire...

CONTEXT Randomized trials have demonstrated that adding a drug to a single-agent or to a 2-agent regimen increased the tumor response rate in patients with advanced non-small-cell lung cancer (NSCLC), although its impact on survival remains controversial. OBJECTIVE To evaluate the clinical benefit of adding a drug to a single-agent or 2-agent chemotherapy regimen in terms of tumor response ra...

Detailed information on additional drug resistance patterns of multidrug-resistant tuberculosis (MDR-TB) is essential to build an effective treatment regimen; however, such data are scarce in Korea. We retrospectively analyzed the results of phenotypic drug susceptibility testing (DST) of culture confirmed-TB patients from January 2010 to December 2014 in 7 university hospitals in Korea. MDR-TB...

BACKGROUND Sentinel testing programs for HIV drug resistance in resource-limited settings can inform policy on antiretroviral therapy (ART) and drug sequencing. OBJECTIVE : To examine the value of resistance surveillance in influencing recommendations toward effective and cost-effective sequencing of ART regimens. METHODS A state-transition model of HIV infection was adapted to simulate cli...

Before hypertension can be considered resistant to a rational triple drug regimen in maximal doses, the physician should rule out poor adherence to the regimen (including diet), adverse drug interactions, pseudotolerance (due to fluid retention), office hypertension, pseudohypertension, and an unrecognized secondary cause (e.g., renovascular disease, primary aldosteronism, and pheochromocytoma)...

Purpose of the study Real world data on the development of drug resistance after virologic failure (VF) on a protease inhibitor (PI)based antiretroviral (ARV) regimen are limited. The I50L substitution in protease is the primary mutation associated with atazanavir drug resistance. The primary objective was to compare the prevalence of I50L from VF patients on an unboosted atazanavir (ATV)-based...