Due to advances in drug delivery technology, currently, excipients are included in novel dosage forms to fulfil specific functions and in some cases they directly or indirectly influence the extent and/or rate of drug release and drug absorption. Recent trends towards use of plant based and natural products demand the replacement of synthetic additives with natural ones. Today, the whole world ...

Natural products provide excellent potential leads for drug development because of their chemical diversity and biological functionality. However, the productivity of discovery of new, pharmacologically active natural products has traditionally been low due to inherent difficulties and costs associated with extract dereplication, i.e., isolation, purification and structure elucidation of indivi...

background and objectives: there is a growing trend towards investigating natural products as sources of compounds with biological effects and many researches have been carried out in order to find effective medications against many diseases. cancer is no exception and studies focusing on evaluating the effects of different materials on dna, give valuable information in cancer researches and ca...

Higher plants are an important source of secondary metabolites such as flavours, fragrances, dyes, pigments, food additives, terpenoids, alkaloids, and glycosides with medicinal importance. Several of these secondary plant products also form the basis for drug development. Today, several countries use plant derived chemicals as drugs with modifications. Unfortunately, these secondary plant prod...

Plant natural products have historically been very important to drug discovery and development, particularly in the anticancer field. This is illustrated by a discussion of the structures and activities of camptothecin and its analogues, paclitaxel (Taxol), the vinca alkaloids vinblastine and vincristine, and podophyllotoxin and its analogues. A description of the isolation of one new and three...

This article has been made to review some medicinal plants used for the treating cancer disease . The plant sources of India are likely to provide effective anticancer agents. Herbs have a vital role in the prevention and treatment of cancer. Examples are provided in this review of promising bioactive compounds obtained from various plants with medicinal and other therapeutic uses. The photoche...

Drug resistance of bacterial pathogens is a growing problem that can be addressed through the discovery of compounds with novel mechanisms of antibacterial activity. Natural products, including plant phenolic compounds, are one source of diverse chemical structures that could inhibit bacteria through novel mechanisms. However, evaluating novel antibacterial mechanisms of action can be difficult...

Constrained, cyclic peptides encoded by plant genes represent a new generation of drug leads. Evolution has repeatedly recruited the Cys-protease asparaginyl endopeptidase (AEP) to perform their head-to-tail ligation. These macrocyclization reactions use the substrates amino terminus instead of water to deacylate, so a peptide bond is formed. How solvent-exposed plant AEPs macrocyclize is poorl...

The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been historically used for divination and shamanism by the Mazatecs. Today, S. divinorum has become increasingly popular as a recreational drug for its hallucinogenic effects. The non-nitrogenous diterpene, salvinorin A, the major active component of S. divinorum, is responsible for the halluc...