background: sustained release delivery system can reduce the dosage frequency and maintain the therapeutic level of drugs for a longer time. biodegradable, biocompatible and thermosensitive chitosan-beta-glycerophosphate (c-gp) solutions can solidify at body temperature and maintain their physical integrity for a longer duration. objectives: to develop a novel delivery system based on the integ...

nanoparticles have been at the center of research focus as a new promising material for the treatment of cancer in recent years. although many chemotherapy drugs for cancer treatment are available, their potential toxicity is the main point of concern. on the other hand, the conventional chemotherapeutic approach has not been found to be very efficient in colorectal cancer (crc) as the drug mol...

objective(s): researchers have intended to reformulate drugs so that they may be more safely used in human body. polymer science and nanotechnology have great roles in this field. the aim of this paper is to introduce an efficient drug delivery vehicle which can perform both targeted and controlled antibiotic release using magnetic nanoparticles grafted ph-responsive polymer.  methods: fe3o4 na...

background topical anesthesia is a safe and cost-effective method considered as the first-choice in many procedures. due to the physiological characteristics of eye, most of the local anesthetics cannot efficiently penetrate through the conjunctiva deep to tenon. the aim of this pilot study was to find a new form of lidocaine to give a sufficient level of anesthesia. methods: lidocaine cyclodex...

background: several multiphase flow analyses have been developed to predict the fate of particles used in inhalation drug delivery; however, the collapse of droplets during their passage through respiratory tract has not been investigated. objective: to assess the probability of droplet collapse in the upper respiratory tract. methods: a 3d model of mouth-to-second generation airway after the t...

conclusions it was shown that combination of pectin and eudragits can relatively control drug release in the upper gi. on the other hand, pectin degraded in the presence of pectinase and formulations were susceptible to the colonic media. results it was shown that in the presence of pectin, formulations without erl had a relative resistance to drug release in sgf. pellets containing pectin and ...

the application of low-frequency ultrasound for transdermal delivery of insulin is of particular public interest due to the increasing problem of diabetes. the purpose of this research was to develop an air ultrasonic ceramic transducer for transdermal insulin delivery and evaluate the possibility of applying a new portable and low-cost device for transdermal insulin delivery. twenty-four rats ...

this review focuses on the latest developments in applications of carbon nanotubes (cnts) in medicine. a brief history of cnts and a general introduction to the field are presented. then, surface modification of cnts that makes them ideal for use in medical applications is highlighted. examples of common applications, including cell penetration, drug delivery, gene delivery and imaging, are giv...

the silver nanoparticles are well-known for their antimicrobial, anti-inflammatory wound healing abilities. we synthesized silver nanoparticles using chemical reduction method and the formation of the silver nanoparticles was characterized by uv-vis absorption spectroscopy, ft-ir and sem techniques. the minimum inhibitory concentration of the synthesized nanoparticles was determined for both gr...